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Macrophage immunomodulation through new polymers that recapitulate functional effects of itaconate as a power house of innate immunity.
Huyer, L Davenport; Mandla, S; Wang, Y; Campbell, S; Yee, B; Euler, C; Lai, B F; Bannerman, D; Lin, D S Y; Montgomery, M; Nemr, K; Bender, T; Epelman, S; Mahadevan, R; Radisic, M.
  • Huyer LD; Department of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, Ontario, Canada.
  • Mandla S; Institute of Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada.
  • Wang Y; Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada.
  • Campbell S; Institute of Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada.
  • Yee B; Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada.
  • Euler C; Department of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, Ontario, Canada.
  • Lai BF; Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada.
  • Bannerman D; Institute of Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada.
  • Lin DSY; Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada.
  • Montgomery M; Department of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, Ontario, Canada.
  • Nemr K; Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada.
  • Bender T; Department of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, Ontario, Canada.
  • Epelman S; Institute of Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada.
  • Mahadevan R; Department of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, Ontario, Canada.
  • Radisic M; Institute of Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada.
Adv Funct Mater ; 31(6)2021 Feb 03.
Article en En | MEDLINE | ID: mdl-33708036
ABSTRACT
Itaconate (ITA) is an emerging powerhouse of innate immunity with therapeutic potential that is limited in its ability to be administered in a soluble form. We developed a library of polyester materials that incorporate ITA into polymer backbones resulting in materials with inherent immunoregulatory behavior. Harnessing hydrolytic degradation release from polyester backbones, ITA polymers resulted in the mechanism specific immunoregulatory properties on macrophage polarization in vitro. In a functional assay, the polymer-released ITA inhibited bacterial growth on acetate. Translation to an in vivo model of biomaterial associated inflammation, intraperitoneal injection of ITA polymers demonstrated a rapid resolution of inflammation in comparison to a control polymer silicone, demonstrating the value of sustained biomimetic presentation of ITA.
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Texto completo: 1 Banco de datos: MEDLINE Idioma: En Año: 2021 Tipo del documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Banco de datos: MEDLINE Idioma: En Año: 2021 Tipo del documento: Article