Topological signatures in regulatory network enable phenotypic heterogeneity in small cell lung cancer.

Chauhan, Lakshya; Ram, Uday; Hari, Kishore; Jolly, Mohit Kumar

Chauhan, Lakshya; Ram, Uday; Hari, Kishore; Jolly, Mohit Kumar.

Chauhan L; Centre for BioSystems Science and Engineering, Indian Institute of Science, Bangalore, India.
Ram U; Undergraduate Programme, Indian Institute of Science, Bangalore, India.
Hari K; Centre for BioSystems Science and Engineering, Indian Institute of Science, Bangalore, India.
Jolly MK; Undergraduate Programme, Indian Institute of Science, Bangalore, India.

Elife ; 102021 03 17.

Article en En | MEDLINE | ID: mdl-33729159

Asunto(s)

Redes Reguladoras de Genes; Neoplasias Pulmonares/genética; Fenotipo; Carcinoma Pulmonar de Células Pequeñas/genética; Proteínas Adaptadoras Transductoras de Señales/genética; Factores de Transcripción con Motivo Hélice-Asa-Hélice Básico/genética; Heterogeneidad Genética; Humanos; Modelos Genéticos; Terapia Molecular Dirigida/métodos; Factores de Transcripción de Octámeros/genética; Factores de Transcripción/genética; Proteínas Señalizadoras YAP

Palabras clave

computational biology; design principles; multistability; network topology; none; phenotypic heterogeneity; physics of living systems; small cell lung cancer; systems biology; toggle switch

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Fenotipo / Redes Reguladoras de Genes / Carcinoma Pulmonar de Células Pequeñas / Neoplasias Pulmonares Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Año: 2021 Tipo del documento: Article

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