Clinical and Descriptive Study of Orofacial Clefts in Colombia: 2069 Patients From Operation Smile Foundation.
Cleft Palate Craniofac J
; 59(2): 200-208, 2022 02.
Article
en En
| MEDLINE
| ID: mdl-33736479
ABSTRACT
OBJECTIVE:
To describe the population of patients with cleft lip and/or palate (CL/P) in terms of cleft phenotypes, gender, age, ethnic group, family history, clinical presentation (syndromic vs nonsyndromic), some environmental and behavioral factors, and some clinical features.DESIGN:
Descriptive retrospective study.SETTING:
Patients attending the genetics counseling practice in Operation Smile Foundation, Bogotá, Colombia, for over 8 years.PARTICIPANTS:
No screening was conducted. All patients requiring clinical genetics assessment in Operation Smile Foundation were included in the study.RESULTS:
Left cleft lip and palate (CLP) and nonsyndromic forms were the most frequent types of malformations in this population. Psychomotor retardation and heart disease were the most frequent comorbidities in these patients. A low proportion of mothers exposed to passive smoking during pregnancy was observed and low birth weight accounted for an important number of cases. Aarskog, velocardiofacial, and orofaciodigital syndromes were the most frequent syndromic forms of CLP in this population.CONCLUSIONS:
In this study, the most frequent type of CL/P was the nonsyndromic complete left CLP. Aarskog, velocardiofacial, and orofaciodigital syndromes were the most frequent syndromic forms of CL/P in this population.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Labio Leporino
/
Fisura del Paladar
Tipo de estudio:
Observational_studies
/
Risk_factors_studies
Límite:
Female
/
Humans
/
Pregnancy
País como asunto:
America do sul
/
Colombia
Idioma:
En
Año:
2022
Tipo del documento:
Article