Anodic Oxidation of Phenols: A Key Step for the Synthesis of Natural Products.
Chem Rec
; 21(9): 2254-2268, 2021 Sep.
Article
en En
| MEDLINE
| ID: mdl-33759336
ABSTRACT
Natural products have played a significant role not only in discovery of drugs but also in development of organic chemistry by providing the synthetic challenges. Inspired by biosynthesis where enzymes catalyze a multi-step reaction, we have investigated the natural product synthesis utilizing electrochemical reactions as the key step. Electrochemical organic synthesis, so-called electro-organic synthesis, enables to control the reactivity of substrates simply by tuning electrolysis conditions. In this Personal Account, we overview the recent progress of our research projects about natural product synthesis, in which anodic oxidation of phenol compounds affords the important frameworks such as diaryl ether, spirodienone, and spiroisoxazoline.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Fenoles
/
Productos Biológicos
Idioma:
En
Año:
2021
Tipo del documento:
Article