MAIT cell activation is associated with disease severity markers in acute hantavirus infection.
Cell Rep Med
; 2(3): 100220, 2021 03 16.
Article
en En
| MEDLINE
| ID: mdl-33763658
ABSTRACT
Hantaviruses are zoonotic RNA viruses that cause severe acute disease in humans. Infected individuals have strong inflammatory responses that likely cause immunopathology. Here, we studied the response of mucosal-associated invariant T (MAIT) cells in peripheral blood of individuals with hemorrhagic fever with renal syndrome (HFRS) caused by Puumala orthohantavirus, a hantavirus endemic in Europe. We show that MAIT cell levels decrease in the blood during HFRS and that residual MAIT cells are highly activated. This activation correlates with HFRS severity markers. In vitro activation of MAIT cells by hantavirus-exposed antigen-presenting cells is dependent on type I interferons (IFNs) and independent of interleukin-18 (IL-18). These findings highlight the role of type I IFNs in virus-driven MAIT cell activation and suggest a potential role of MAIT cells in the disease pathogenesis of viral infections.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Activación de Linfocitos
/
Infecciones por Hantavirus
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Virus Puumala
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Células T Invariantes Asociadas a Mucosa
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Fiebre Hemorrágica con Síndrome Renal
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Células Presentadoras de Antígenos
Tipo de estudio:
Observational_studies
/
Risk_factors_studies
Idioma:
En
Año:
2021
Tipo del documento:
Article