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Discovery of Ethyl Ketone-Based Highly Selective HDACs 1, 2, 3 Inhibitors for HIV Latency Reactivation with Minimum Cellular Potency Serum Shift and Reduced hERG Activity.
Yu, Wensheng; Liu, Jian; Clausen, Dane; Yu, Younong; Duffy, Joseph L; Wang, Ming; Xu, Shouning; Deng, Lin; Suzuki, Takao; Chung, Christine C; Myers, Robert W; Klein, Daniel J; Fells, James I; Holloway, M Katharine; Wu, Jin; Wu, Guoxin; Howell, Bonnie J; Barnard, Richard J O; Kozlowski, Joseph.
  • Yu W; Merck & Co. Inc., 2000 Galloping Hill Road, Kenilworth, New Jersey 07033, United States.
  • Liu J; Merck & Co. Inc., 2000 Galloping Hill Road, Kenilworth, New Jersey 07033, United States.
  • Clausen D; Merck & Co. Inc., 2000 Galloping Hill Road, Kenilworth, New Jersey 07033, United States.
  • Yu Y; Merck & Co. Inc., 2000 Galloping Hill Road, Kenilworth, New Jersey 07033, United States.
  • Duffy JL; Merck & Co. Inc., 2000 Galloping Hill Road, Kenilworth, New Jersey 07033, United States.
  • Wang M; Merck & Co. Inc., 2000 Galloping Hill Road, Kenilworth, New Jersey 07033, United States.
  • Xu S; WuXi AppTec, 288 Fute Zhong Road, Shanghai 200131, China.
  • Deng L; WuXi AppTec, 288 Fute Zhong Road, Shanghai 200131, China.
  • Suzuki T; WuXi AppTec, 288 Fute Zhong Road, Shanghai 200131, China.
  • Chung CC; Merck & Co. Inc., 2000 Galloping Hill Road, Kenilworth, New Jersey 07033, United States.
  • Myers RW; Merck & Co. Inc., 2000 Galloping Hill Road, Kenilworth, New Jersey 07033, United States.
  • Klein DJ; Merck & Co. Inc., 770 Sumneytown Pike, West Point, Pennsylvania 19486, United States.
  • Fells JI; Merck & Co. Inc., 770 Sumneytown Pike, West Point, Pennsylvania 19486, United States.
  • Holloway MK; Merck & Co. Inc., 770 Sumneytown Pike, West Point, Pennsylvania 19486, United States.
  • Wu J; Merck & Co. Inc., 2000 Galloping Hill Road, Kenilworth, New Jersey 07033, United States.
  • Wu G; Merck & Co. Inc., 770 Sumneytown Pike, West Point, Pennsylvania 19486, United States.
  • Howell BJ; Merck & Co. Inc., 770 Sumneytown Pike, West Point, Pennsylvania 19486, United States.
  • Barnard RJO; Merck & Co. Inc., 770 Sumneytown Pike, West Point, Pennsylvania 19486, United States.
  • Kozlowski J; Merck & Co. Inc., 2000 Galloping Hill Road, Kenilworth, New Jersey 07033, United States.
J Med Chem ; 64(8): 4709-4729, 2021 04 22.
Article en En | MEDLINE | ID: mdl-33797924
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: VIH-1 / Inhibidores de Histona Desacetilasas / Canal de Potasio ERG1 / Histona Desacetilasas / Cetonas Límite: Animals / Humans Idioma: En Año: 2021 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: VIH-1 / Inhibidores de Histona Desacetilasas / Canal de Potasio ERG1 / Histona Desacetilasas / Cetonas Límite: Animals / Humans Idioma: En Año: 2021 Tipo del documento: Article