The Agonist Action of Alkylphenols on TRPA1 Relates to Their Effects on Membrane Lipid Order: Implications for TRPA1-Mediated Chemosensation.

Startek, Justyna B; Milici, Alina; Naert, Robbe; Segal, Andrei; Alpizar, Yeranddy A; Voets, Thomas; Talavera, Karel

Startek, Justyna B; Milici, Alina; Naert, Robbe; Segal, Andrei; Alpizar, Yeranddy A; Voets, Thomas; Talavera, Karel.

Startek JB; Laboratory of Ion Channel Research, Department of Cellular and Molecular Medicine, KU Leuven, 3000 Leuven, Belgium.
Milici A; VIB Center for Brain & Disease Research, 3000 Leuven, Belgium.
Naert R; Laboratory of Ion Channel Research, Department of Cellular and Molecular Medicine, KU Leuven, 3000 Leuven, Belgium.
Segal A; VIB Center for Brain & Disease Research, 3000 Leuven, Belgium.
Alpizar YA; Laboratory of Ion Channel Research, Department of Cellular and Molecular Medicine, KU Leuven, 3000 Leuven, Belgium.
Voets T; VIB Center for Brain & Disease Research, 3000 Leuven, Belgium.
Talavera K; Laboratory of Ion Channel Research, Department of Cellular and Molecular Medicine, KU Leuven, 3000 Leuven, Belgium.

Int J Mol Sci ; 22(7)2021 Mar 25.

Article en En | MEDLINE | ID: mdl-33806007

Asunto(s)

Membrana Celular/metabolismo; Fenoles/farmacología; Canal Catiónico TRPA1/agonistas; Animales; Anisotropía; Células CHO; Calcio/metabolismo; Canales de Calcio/metabolismo; Carbono/química; Cricetulus; Relación Dosis-Respuesta a Droga; Células HEK293; Humanos; Ligandos; Lípidos de la Membrana; Ratones; Nociceptores/metabolismo; Estrés Oxidativo

Palabras clave

DPH; Laurdan; TRPA1; alkylphenols; mechanosensation; membrane fluidity

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Fenoles / Membrana Celular / Canal Catiónico TRPA1 Límite: Animals / Humans Idioma: En Año: 2021 Tipo del documento: Article

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