Aberrant expression of cytokines in polycythemia vera correlate with the risk of thrombosis.
Blood Cells Mol Dis
; 89: 102565, 2021 07.
Article
en En
| MEDLINE
| ID: mdl-33831662
ABSTRACT
BACKGROUND:
Thrombo-hemorrhagic complications cause significant morbidity and mortality in patients with polycythemia vera (PV).OBJECTIVES:
To assay and correlate inflammatory cytokines with the thrombotic risk in PV patients.METHODS:
This prospective observational study was carried out at Postgraduate Institute of Medical Education and Research, Chandigarh, India over 18-months. The study enrolled 52 patients with PV (newly diagnosed = 28, follow-up = 24), and 20 age/sex-matched controls. Cytokine analysis for IL 1ß, IL2, IL4, IL6, IL8, IL10, IL11, IL12/23p40, TNFα, and IFN-γ was performed on the peripheral blood (before treatment initiation for newly diagnosed cases, and after 7 days of stopping drugs for follow-up cases) by flow cytometry-based cytokine bead analysis (CBA) using CBA kits (BD™ biosciences, USA). Results were analyzed using SPSS Statistics 22.0.RESULTS:
The mean age of patients was 51.9 ± 13 years. Levels of IL-6, IL-1ß, IL-8, IL-11, IL-12/23p40 were significantly raised, however, TNF-α, and IFN-γ levels were significantly lower in the PV population as compared to controls. A significant correlation between the levels of IL-6, IL-2, and IL-8 with the overall risk of thrombosis in PV patients was observed.CONCLUSIONS:
PV patients display an aberrant pattern of plasma cytokine expression, the levels of which correlate with the thrombotic risk.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Policitemia Vera
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Trombosis
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Citocinas
Tipo de estudio:
Etiology_studies
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Observational_studies
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Risk_factors_studies
Límite:
Adult
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Año:
2021
Tipo del documento:
Article