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Microtubule and tubulin binding and regulation of microtubule dynamics by the antibody drug conjugate (ADC) payload, monomethyl auristatin E (MMAE): Mechanistic insights into MMAE ADC peripheral neuropathy.
Best, Rebecca L; LaPointe, Nichole E; Azarenko, Olga; Miller, Herb; Genualdi, Christine; Chih, Stephen; Shen, Ben-Quan; Jordan, Mary Ann; Wilson, Leslie; Feinstein, Stuart C; Stagg, Nicola J.
  • Best RL; Neuroscience Research Institute and Department of Molecular, Cellular and Developmental Biology, University of California, Santa Barbara, CA 93106, USA.
  • LaPointe NE; Neuroscience Research Institute and Department of Molecular, Cellular and Developmental Biology, University of California, Santa Barbara, CA 93106, USA.
  • Azarenko O; Neuroscience Research Institute and Department of Molecular, Cellular and Developmental Biology, University of California, Santa Barbara, CA 93106, USA.
  • Miller H; Neuroscience Research Institute and Department of Molecular, Cellular and Developmental Biology, University of California, Santa Barbara, CA 93106, USA.
  • Genualdi C; Safety Assessment, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Chih S; Neuroscience Research Institute and Department of Molecular, Cellular and Developmental Biology, University of California, Santa Barbara, CA 93106, USA.
  • Shen BQ; Preclinical and Translational PK, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Jordan MA; Neuroscience Research Institute and Department of Molecular, Cellular and Developmental Biology, University of California, Santa Barbara, CA 93106, USA.
  • Wilson L; Neuroscience Research Institute and Department of Molecular, Cellular and Developmental Biology, University of California, Santa Barbara, CA 93106, USA.
  • Feinstein SC; Neuroscience Research Institute and Department of Molecular, Cellular and Developmental Biology, University of California, Santa Barbara, CA 93106, USA. Electronic address: feinstei@lifesci.ucsb.edu.
  • Stagg NJ; Safety Assessment, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA. Electronic address: stagg.nicola@gene.com.
Toxicol Appl Pharmacol ; 421: 115534, 2021 06 15.
Article en En | MEDLINE | ID: mdl-33852878
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Oligopéptidos / Tubulina (Proteína) / Neoplasias de la Mama / Sistema Nervioso Periférico / Enfermedades del Sistema Nervioso Periférico / Moduladores de Tubulina / Microtúbulos Tipo de estudio: Etiology_studies / Risk_factors_studies Límite: Female / Humans Idioma: En Año: 2021 Tipo del documento: Article
Texto completo
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Oligopéptidos / Tubulina (Proteína) / Neoplasias de la Mama / Sistema Nervioso Periférico / Enfermedades del Sistema Nervioso Periférico / Moduladores de Tubulina / Microtúbulos Tipo de estudio: Etiology_studies / Risk_factors_studies Límite: Female / Humans Idioma: En Año: 2021 Tipo del documento: Article