mi-IsoNet: systems-scale microRNA landscape reveals rampant isoform-mediated gain of target interaction diversity and signaling specificity.

Guo, Li; Li, Yongsheng; Cirillo, Kara M; Marick, Robert A; Su, Zhe; Yin, Xing; Hua, Xu; Mills, Gordon B; Sahni, Nidhi; Yi, S Stephen

Guo, Li; Li, Yongsheng; Cirillo, Kara M; Marick, Robert A; Su, Zhe; Yin, Xing; Hua, Xu; Mills, Gordon B; Sahni, Nidhi; Yi, S Stephen.

Guo L; Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Li Y; Department of Oncology, Livestrong Cancer Institutes, Dell Medical School, The University of Texas at Austin, Austin, TX 78712, USA.
Cirillo KM; Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Smithville, TX 78957, USA.
Marick RA; Department of Oncology, Livestrong Cancer Institutes, Dell Medical School, The University of Texas at Austin, Austin, TX 78712, USA.
Su Z; Department of Oncology, Livestrong Cancer Institutes, Dell Medical School, The University of Texas at Austin, Austin, TX 78712, USA.
Yin X; Department of Oncology, Livestrong Cancer Institutes, Dell Medical School, The University of Texas at Austin, Austin, TX 78712, USA.
Hua X; Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Mills GB; Department of Cell, Developmental and Cancer Biology, School of Medicine, Oregon Health & Science University, Portland, OR 97201, USA.
Sahni N; Precision Oncology, Knight Cancer Institute, Portland, OR 97201, USA.
Yi SS; Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Smithville, TX 78957, USA.

Brief Bioinform ; 22(5)2021 09 02.

Article en En | MEDLINE | ID: mdl-33855356

Asunto(s)

Biología Computacional/métodos; Perfilación de la Expresión Génica/métodos; Regulación Neoplásica de la Expresión Génica; MicroARNs/genética; Neoplasias/genética; Isoformas de ARN/genética; Análisis por Conglomerados; Redes Reguladoras de Genes; Variación Genética; Secuenciación de Nucleótidos de Alto Rendimiento/métodos; Humanos; Neoplasias/metabolismo; ARN Mensajero/genética; Transducción de Señal/genética; Análisis de Supervivencia

Palabras clave

functional diversity; gain of interactions; gene regulatory networks; isoforms; microRNA (miRNA); signaling specificity

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Regulación Neoplásica de la Expresión Génica / Biología Computacional / Perfilación de la Expresión Génica / MicroARNs / Isoformas de ARN / Neoplasias Límite: Humans Idioma: En Año: 2021 Tipo del documento: Article

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