Antibiotic resistance heterogeneity and LasR diversity within Pseudomonas aeruginosa populations from pneumonia in intensive care unit patients.
Int J Antimicrob Agents
; 57(6): 106341, 2021 Jun.
Article
en En
| MEDLINE
| ID: mdl-33857540
ABSTRACT
This study investigated within-host heterogeneity of 66 Pseudomonas aeruginosa populations from pneumonia in 51 critically ill ventilated patients by examining 30 colonies per bronchoalveolar lavage (BAL). Differences in antibiotic susceptibility and quorum-sensing (QS) phenotypes were observed between the members of 14 (21.2%) and 10 (15.2%) populations, respectively. A significant association was found between QS deficiency and ceftazidime resistance. QS deficiency was associated with various lasR modifications, and was observed in 25 of 51 (49.0%) patients, including seven patients who received ≤48 h of ventilation. This study confirms the need to examine diverse colonies when analysing BAL cultures, particularly in ß-lactam-exposed patients, to avoid missing ceftazidime- or imipenem-resistant isolates.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Neumonía
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Pseudomonas aeruginosa
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Infecciones por Pseudomonas
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Proteínas Bacterianas
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Transactivadores
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Farmacorresistencia Bacteriana
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Antibacterianos
Límite:
Humans
Idioma:
En
Año:
2021
Tipo del documento:
Article