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Recent knowledge in favor of remdesivir (GS-5734) as a therapeutic option for the COVID-19 infections.
Saqrane, S; El Mhammedi, M A; Lahrich, S; Laghrib, F; El Bouabi, Y; Farahi, A; Bakasse, M.
  • Saqrane S; Sultan Moulay Slimane University of Beni Mellal, Laboratory of Chemistry, Modeling and Environmental Sciences, Polydisciplinary Faculty, 25 000 Khouribga, Morocco.
  • El Mhammedi MA; Sultan Moulay Slimane University of Beni Mellal, Laboratory of Chemistry, Modeling and Environmental Sciences, Polydisciplinary Faculty, 25 000 Khouribga, Morocco. Electronic address: elmhammedi@yahoo.fr.
  • Lahrich S; Sultan Moulay Slimane University of Beni Mellal, Laboratory of Chemistry, Modeling and Environmental Sciences, Polydisciplinary Faculty, 25 000 Khouribga, Morocco.
  • Laghrib F; Sultan Moulay Slimane University of Beni Mellal, Laboratory of Chemistry, Modeling and Environmental Sciences, Polydisciplinary Faculty, 25 000 Khouribga, Morocco.
  • El Bouabi Y; Sultan Moulay Slimane University of Beni Mellal, Laboratory of Chemistry, Modeling and Environmental Sciences, Polydisciplinary Faculty, 25 000 Khouribga, Morocco.
  • Farahi A; Sultan Moulay Slimane University of Beni Mellal, Laboratory of Chemistry, Modeling and Environmental Sciences, Polydisciplinary Faculty, 25 000 Khouribga, Morocco.
  • Bakasse M; Sultan Moulay Slimane University of Beni Mellal, Laboratory of Chemistry, Modeling and Environmental Sciences, Polydisciplinary Faculty, 25 000 Khouribga, Morocco.
J Infect Public Health ; 14(5): 655-660, 2021 May.
Article en En | MEDLINE | ID: mdl-33857725
ABSTRACT
The management of SARS-CoV-2 has not yet been clearly determined and is based on potential therapies evaluated during the SARS-CoV and MERS-CoV outbreaks. An emerging potential therapeutic approach currently being evaluated in numerous clinical trials is the remdesivir agent, which acts on COVID-19 by interfering with key steps in the virus replication cycle. It is considered a therapeutic option to be evaluated against COVID-19, based on data on its in vitro and in vivo activity against MERS-CoV and SARS-CoV coronaviruses. In this work, we provide an overview of remdesivir's discovery, mechanism of action, and the current studies exploring its clinical effectiveness. Recommendations for its use against COVID-19 infection are also summarized.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Tratamiento Farmacológico de COVID-19 Tipo de estudio: Guideline Límite: Humans Idioma: En Año: 2021 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Tratamiento Farmacológico de COVID-19 Tipo de estudio: Guideline Límite: Humans Idioma: En Año: 2021 Tipo del documento: Article