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Small-molecule inhibition of METTL3 as a strategy against myeloid leukaemia.
Yankova, Eliza; Blackaby, Wesley; Albertella, Mark; Rak, Justyna; De Braekeleer, Etienne; Tsagkogeorga, Georgia; Pilka, Ewa S; Aspris, Demetrios; Leggate, Dan; Hendrick, Alan G; Webster, Natalie A; Andrews, Byron; Fosbeary, Richard; Guest, Patrick; Irigoyen, Nerea; Eleftheriou, Maria; Gozdecka, Malgorzata; Dias, Joao M L; Bannister, Andrew J; Vick, Binje; Jeremias, Irmela; Vassiliou, George S; Rausch, Oliver; Tzelepis, Konstantinos; Kouzarides, Tony.
  • Yankova E; Milner Therapeutics Institute, University of Cambridge, Cambridge, UK.
  • Blackaby W; Haematological Cancer Genetics, Wellcome Trust Sanger Institute, Cambridge, UK.
  • Albertella M; Storm Therapeutics Ltd, Cambridge, UK.
  • Rak J; Storm Therapeutics Ltd, Cambridge, UK.
  • De Braekeleer E; Storm Therapeutics Ltd, Cambridge, UK.
  • Tsagkogeorga G; Haematological Cancer Genetics, Wellcome Trust Sanger Institute, Cambridge, UK.
  • Pilka ES; Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.
  • Aspris D; Haematological Cancer Genetics, Wellcome Trust Sanger Institute, Cambridge, UK.
  • Leggate D; Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.
  • Hendrick AG; Milner Therapeutics Institute, University of Cambridge, Cambridge, UK.
  • Webster NA; Storm Therapeutics Ltd, Cambridge, UK.
  • Andrews B; Evotec (UK) Ltd, Abingdon, UK.
  • Fosbeary R; Haematological Cancer Genetics, Wellcome Trust Sanger Institute, Cambridge, UK.
  • Guest P; The Center for the Study of Hematological Malignancies/Karaiskakio Foundation, Nicosia, Cyprus.
  • Irigoyen N; Storm Therapeutics Ltd, Cambridge, UK.
  • Eleftheriou M; Storm Therapeutics Ltd, Cambridge, UK.
  • Gozdecka M; Storm Therapeutics Ltd, Cambridge, UK.
  • Dias JML; Storm Therapeutics Ltd, Cambridge, UK.
  • Bannister AJ; Storm Therapeutics Ltd, Cambridge, UK.
  • Vick B; Storm Therapeutics Ltd, Cambridge, UK.
  • Jeremias I; Division of Virology, Department of Pathology, University of Cambridge, Cambridge, UK.
  • Vassiliou GS; Milner Therapeutics Institute, University of Cambridge, Cambridge, UK.
  • Rausch O; Haematological Cancer Genetics, Wellcome Trust Sanger Institute, Cambridge, UK.
  • Tzelepis K; MRC Cancer Unit, University of Cambridge, Hutchison/MRC Research Centre, Cambridge, UK.
  • Kouzarides T; The Gurdon Institute and Department of Pathology, University of Cambridge, Cambridge, UK.
Nature ; 593(7860): 597-601, 2021 05.
Article en En | MEDLINE | ID: mdl-33902106
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Leucemia Mieloide Aguda / Metiltransferasas / Antineoplásicos Límite: Animals / Female / Humans Idioma: En Año: 2021 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Leucemia Mieloide Aguda / Metiltransferasas / Antineoplásicos Límite: Animals / Female / Humans Idioma: En Año: 2021 Tipo del documento: Article