The Habitat Filters of Microbiota-Nourishing Immunity.
Annu Rev Immunol
; 39: 1-18, 2021 04 26.
Article
en En
| MEDLINE
| ID: mdl-33902314
ABSTRACT
An imbalance in the microbiota may contribute to many human illnesses, which has prompted efforts to rebalance it by targeting the microbes themselves. However, by supplying the habitat, the host wields a prominent influence over microbial growth at body surfaces, raising the possibility that rebalancing the microbiota by targeting our immune system would be a viable alternative. Host control mechanisms that sculpt the microbial habitat form a functional unit with the microbiota, termed microbiota-nourishing immunity, that confers colonization resistance against pathogens. The host components of microbiota-nourishing immunity can be viewed as habitat filters that select for microbial traits licensing growth and survival in host habitat patches. Here we review current knowledge of how host-derived habitat filters shape the size, species composition, and spatial heterogeneity of the microbiota and discuss whether these host control mechanisms could be harnessed for developing approaches to rebalance microbial communities during dysbiosis.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Disbiosis
/
Microbiota
Límite:
Animals
/
Humans
Idioma:
En
Año:
2021
Tipo del documento:
Article