Stepwise generation of AID knock-in and conditional knockout mice from a single gene-targeting event.

Kinoshita, Kazuo; Uemura, Munehiro; Shimizu, Takahiro; Kinoshita, Shun; Marusawa, Hiroyuki

Kinoshita, Kazuo; Uemura, Munehiro; Shimizu, Takahiro; Kinoshita, Shun; Marusawa, Hiroyuki.

Kinoshita K; Evolutionary Medicine, Shizuoka Graduate University of Public Health, 4-27-2 Kita-ando, Aoi-ku, Shizuoka 420-0881, Japan.
Uemura M; Shiga Medical Center Research Institute, Moriyama 524-0022, Japan.
Shimizu T; Shiga Medical Center Research Institute, Moriyama 524-0022, Japan.
Kinoshita S; Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto 606-8501, Japan.
Marusawa H; Kyoto University Graduate School of Medicine Faculty of Medicine, Kyoto 606-8501, Japan.

Int Immunol ; 33(7): 387-398, 2021 06 18.

Article en En | MEDLINE | ID: mdl-33903914

Asunto(s)

Citidina Desaminasa/genética; Animales; Linfocitos B/metabolismo; Epigénesis Genética/genética; Femenino; Centro Germinal/metabolismo; Cambio de Clase de Inmunoglobulina/genética; Masculino; Ratones; Ratones Endogámicos BALB C; Ratones Endogámicos C57BL; Ratones Noqueados; Regiones Promotoras Genéticas/genética

Palabras clave

activation-induced cytidine deaminase; antibody diversity; class switch; red fluorescent protein; somatic hypermutation

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Citidina Desaminasa Límite: Animals Idioma: En Año: 2021 Tipo del documento: Article

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Citidina Desaminasa Límite: Animals Idioma: En Año: 2021 Tipo del documento: Article