A survey among German-speaking radiation oncologists on PET-based radiotherapy of prostate cancer.
Radiat Oncol
; 16(1): 82, 2021 May 01.
Article
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| MEDLINE
| ID: mdl-33933111
ABSTRACT
BACKGROUND:
Positron emission tomography-(PET) has evolved as a powerful tool to guide treatment for prostate cancer (PC). The aim of this survey was to evaluate the acceptance and use of PET-especially with prostate-specific membrane antigen (PSMA) targeting tracers-in clinical routine for radiotherapy (RT) and the impact on target volume definition and dose prescription.METHODS:
We developed an online survey, which we distributed via e-mail to members of the German Society of Radiation Oncology (DEGRO). The survey included questions on patterns of care of RT for PC with/without PET. For evaluation of doses we used the equivalent dose at fractionation of 2 Gy with α/ß = 1.5 Gy [EQD2(1.5 Gy)].RESULTS:
From 109 participants, 78.9% have the possibility to use PET for RT planning. Most centers use PSMA-targeting tracers (98.8%). In 39.5%, PSMA-PET for biochemical relapse after prior surgery is initiated at PSA ≥ 0.5 ng/mL, while 30.2% will perform PET at ≥ 0.2 ng/mL (≥ 1.0 ng/mL 16.3%, ≥ 2.0 ng/mL 2.3%, regardless of PSA 11.7%). In case of PET-positive local recurrence (LR) and pelvic lymph nodes (LNs), 97.7% and 96.5% of the participants will apply an escalated dose. The median total dose in EQD2(1.5 Gy) was 70.00 Gy (range 56.89-85.71) for LR and 62.00 Gy (range 52.61-80.00) for LNs. A total number of ≤ 3 (22.0%) or ≤ 5 (20.2%) distant lesions was most often described as applicable for the definition as oligometastatic PC.CONCLUSION:
PSMA-PET is widely used among German radiation oncologists. However, specific implications on treatment planning differ among physicians. Therefore, further trials and guidelines for PET-based RT are warranted.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Neoplasias de la Próstata
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Planificación de la Radioterapia Asistida por Computador
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Tomografía Computarizada por Tomografía de Emisión de Positrones
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Oncólogos de Radiación
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Lenguaje
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Recurrencia Local de Neoplasia
Tipo de estudio:
Guideline
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Prognostic_studies
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Qualitative_research
Límite:
Humans
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Male
País como asunto:
Europa
Idioma:
En
Año:
2021
Tipo del documento:
Article