Extracellular Vesicles from Human Umbilical Cord Mesenchymal Stem Cells Facilitate Diabetic Wound Healing Through MiR-17-5p-mediated Enhancement of Angiogenesis.

Wei, Qian; Wang, Yaxi; Ma, Kui; Li, Qiankun; Li, Bingmin; Hu, Wenzhi; Fu, Xiaobing; Zhang, Cuiping

Wei, Qian; Wang, Yaxi; Ma, Kui; Li, Qiankun; Li, Bingmin; Hu, Wenzhi; Fu, Xiaobing; Zhang, Cuiping.

Wei Q; Research Center for Tissue Repair and Regeneration Affiliated to the Medical Innovation Research Division and 4th Medical Center of Chinese PLA General Hospital, 51 Fucheng Road, Haidian District, Beijing, 100048, China.
Wang Y; Chinese PLA Medical School, 28 Fuxing Road, Haidian District, 100853, Beijing, China.
Ma K; Research Center for Tissue Repair and Regeneration Affiliated to the Medical Innovation Research Division and 4th Medical Center of Chinese PLA General Hospital, 51 Fucheng Road, Haidian District, Beijing, 100048, China.
Li Q; Chinese PLA Medical School, 28 Fuxing Road, Haidian District, 100853, Beijing, China.
Li B; Research Center for Tissue Repair and Regeneration Affiliated to the Medical Innovation Research Division and 4th Medical Center of Chinese PLA General Hospital, 51 Fucheng Road, Haidian District, Beijing, 100048, China.
Hu W; Research Unit of Trauma Care, Tissue Repair and Regeneration, Chinese Academy of Medical Sciences, 2019RU051, 51 Fucheng Road, Haidian District, 100048, Beijing, China.
Fu X; Beijing Key Research Laboratory of Skin Injury, Repair and Regeneration, 51 Fucheng Road, Haidian District, 100048, Beijing, China.
Zhang C; Research Center for Tissue Repair and Regeneration Affiliated to the Medical Innovation Research Division and 4th Medical Center of Chinese PLA General Hospital, 51 Fucheng Road, Haidian District, Beijing, 100048, China.

Stem Cell Rev Rep ; 18(3): 1025-1040, 2022 03.

Article en En | MEDLINE | ID: mdl-33942217

Asunto(s)

Diabetes Mellitus; Vesículas Extracelulares; Células Madre Mesenquimatosas; MicroARNs; Células Endoteliales/metabolismo; Vesículas Extracelulares/metabolismo; Humanos; Células Madre Mesenquimatosas/metabolismo; MicroARNs/genética; MicroARNs/metabolismo; Neovascularización Patológica/metabolismo; Proteínas Proto-Oncogénicas c-akt/metabolismo; Cordón Umbilical/metabolismo; Factor A de Crecimiento Endotelial Vascular/genética; Factor A de Crecimiento Endotelial Vascular/metabolismo; Cicatrización de Heridas/genética

Palabras clave

Angiogenesis; Diabetic wounds; Extracellular vesicles; Mesenchymal stem cells; miR-17-5p/PTEN/AKT/HIF-1α/VEGF pathway

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: MicroARNs / Diabetes Mellitus / Células Madre Mesenquimatosas / Vesículas Extracelulares Límite: Humans Idioma: En Año: 2022 Tipo del documento: Article

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