One-pot green synthesis of I@CNDs-Fe3O4 hybrid nanoparticles from kelp for multi-modal imaging in vivo.

ABSTRACT

Multi-modal imaging technologies are playing an increasingly important role in biomedical research. However, there remains a demanding challenge to develop biocompatible contrast agents via a simple, green synthetic route for multi-modal imaging. Here we report the synthesis and applications of a new contrast agent for triple-modal imaging, that is, iodine-containing N-doping carbon nano-dots hybridized with Fe3O4 nanoparticles (I@CNDs-Fe3O4). We develop a one-pot, environment friendly hydrothermal method to synthesize the hybrid nanoparticles, primarily using kelp as the bioresource. I@CNDs-Fe3O4 nanoparticles have been demonstrated to exhibit excellent multi-modal imaging capabilities, including wavelength-tunable fluorescent imaging, X-ray attenuation for CT imaging enhancement, and T2-Weighted MR imaging. Importantly, the formulation of the hybrid nanoparticle provides an optimal solution to address the disequilibrium of osmotic pressure caused by the conventional CT imaging contrast agents of iodine compounds. The I@CNDs-Fe3O4 nanoparticles promise important applications in multi-modal imaging technologies in vivo as a versatile and biocompatible contrast agent.