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Effect of hyperparathyroidism on coagulation: a global assessment by modified rotation thromboelastogram (ROTEM)
Yorulmaz, Göknur; Kalkan, Ahmet Toygar; Akalin, Aysen; Alagüney, Elif Sevil; Gündüz, Eren; Badak, Bartu; Buyruk, Betül Aydin; Kebapçi, Nur; Efe, Belgin; Bilgin, Muzaffer; Akay, Olga Meltem.
  • Yorulmaz G; Department of Endocrinology and Metabolism, Faculty of Medicine, Eskisehir Osmangazi University, Eskisehir, Turkey
  • Kalkan AT; Department of Endocrinology and Metabolism, Faculty of Medicine, Eskisehir Osmangazi University, Eskisehir, Turkey
  • Akalin A; Department of Endocrinology and Metabolism, Faculty of Medicine, Eskisehir Osmangazi University, Eskisehir, Turkey
  • Alagüney ES; Department of Endocrinology and Metabolism, Faculty of Medicine, Eskisehir Osmangazi University, Eskisehir, Turkey
  • Gündüz E; Department of Hematology, Faculty of Medicine, Eskisehir Osmangazi University, Eskisehir, Turkey
  • Badak B; Departments of General Surgery, Faculty of Medicine, Eskisehir Osmangazi University, Eskisehir, Turkey
  • Buyruk BA; Department of Endocrinology and Metabolism, Faculty of Medicine, Eskisehir Osmangazi University, Eskisehir, Turkey
  • Kebapçi N; Department of Endocrinology and Metabolism, Faculty of Medicine, Eskisehir Osmangazi University, Eskisehir, Turkey
  • Efe B; Department of Endocrinology and Metabolism, Faculty of Medicine, Eskisehir Osmangazi University, Eskisehir, Turkey
  • Bilgin M; Department of Biostatistics and Medical Informatics, Faculty of Medicine, Eskisehir Osmangazi University, Eskisehir, Turkey
  • Akay OM; Department of Hematology, Faculty of Medicine, Koç University, Istanbul
Turk J Med Sci ; 51(6): 2897-2902, 2021 12 13.
Article en En | MEDLINE | ID: mdl-33957726
Background/aim: Hyperparathyroidism is an endocrine disorder characterized by hypercalcemia. Because of calcium's effects on parathyroid glands, bone, intestines, and kidneys, it has an important place in homeostasis. The results of studies regarding hyperparathyroidism hemostasis are conflicting. Thromboelastography helps to evaluate all steps of hemostatic system. Our aim in this study was to investigate the possible role of hemostatic mechanisms in the development of thrombosis in hyperparathyroid patients with the modified rotation thromboelastogram (ROTEM). Materials and methods: Twenty-two patients with primary hyperparathyroidism (PHPT) and 20 healthy controls were involved. This study was conducted in Eskisehir Osmangazi University Faculty of Medicine, Endocrinology and Hematology clinics for 2 years. The complete blood count, fibrinogen, D-dimer levels, prothrombin time, activated prothrombin time, and ROTEM parameters [clot formation time (CFT), clotting time (CT), and maximum clot formation (MCF)] were determined by two activated tests, INTEM and EXTEM analyses. A thromboelastographic evaluation was performed in the preoperative and postoperative (3 months after surgery) periods. Results: In INTEM assay, the CT (p = 0.012) and CFT (p = 0.07) values were increased in preoperative PHPT patients compared with the control group. Although there was a decrease in the postoperative CT and CFT values, no statistical difference was found. Conclusion: The prolongation of the CT and CFT values were consistent with a hypocoagulable state in patients with PHPT. Hyperparathyroidism causes a hypocoagulable state that can be successfully assessed by ROTEM. Hemostatic changes, do not seem to have an effect on increased cardiovascular mortality.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Tromboelastografía / Coagulación Sanguínea / Hemostáticos / Hiperparatiroidismo Límite: Female / Humans / Male / Middle aged Idioma: En Año: 2021 Tipo del documento: Article

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Tromboelastografía / Coagulación Sanguínea / Hemostáticos / Hiperparatiroidismo Límite: Female / Humans / Male / Middle aged Idioma: En Año: 2021 Tipo del documento: Article