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Genome-wide survival study identifies a novel synaptic locus and polygenic score for cognitive progression in Parkinson's disease.
Liu, Ganqiang; Peng, Jiajie; Liao, Zhixiang; Locascio, Joseph J; Corvol, Jean-Christophe; Zhu, Frank; Dong, Xianjun; Maple-Grødem, Jodi; Campbell, Meghan C; Elbaz, Alexis; Lesage, Suzanne; Brice, Alexis; Mangone, Graziella; Growdon, John H; Hung, Albert Y; Schwarzschild, Michael A; Hayes, Michael T; Wills, Anne-Marie; Herrington, Todd M; Ravina, Bernard; Shoulson, Ira; Taba, Pille; Kõks, Sulev; Beach, Thomas G; Cormier-Dequaire, Florence; Alves, Guido; Tysnes, Ole-Bjørn; Perlmutter, Joel S; Heutink, Peter; Amr, Sami S; van Hilten, Jacobus J; Kasten, Meike; Mollenhauer, Brit; Trenkwalder, Claudia; Klein, Christine; Barker, Roger A; Williams-Gray, Caroline H; Marinus, Johan; Scherzer, Clemens R.
  • Liu G; Center for Advanced Parkinson Research, Harvard Medical School, Brigham and Women's Hospital, Boston, MA, USA.
  • Peng J; Precision Neurology Program of Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
  • Liao Z; School of Medicine, Sun Yat-sen University, Shenzhen, Guangdong, China.
  • Locascio JJ; Center for Advanced Parkinson Research, Harvard Medical School, Brigham and Women's Hospital, Boston, MA, USA.
  • Corvol JC; Precision Neurology Program of Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
  • Zhu F; School of Computer Science, Northwestern Polytechnical University, Xi'an, Shaanxi, China.
  • Dong X; Center for Advanced Parkinson Research, Harvard Medical School, Brigham and Women's Hospital, Boston, MA, USA.
  • Maple-Grødem J; Precision Neurology Program of Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
  • Campbell MC; Center for Advanced Parkinson Research, Harvard Medical School, Brigham and Women's Hospital, Boston, MA, USA.
  • Elbaz A; Precision Neurology Program of Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
  • Lesage S; Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
  • Brice A; Sorbonne Université, Paris Brain Institute - Institut du Cerveau - ICM, Institut National de Santé et en Recherche Médicale, Centre National de Recherche Scientifique, Assistance Publique Hôpitaux de Paris, Département de Neurologie et de Génétique, Centre d'Investigation Clinique Neurosciences, Hôp
  • Mangone G; Center for Advanced Parkinson Research, Harvard Medical School, Brigham and Women's Hospital, Boston, MA, USA.
  • Growdon JH; Precision Neurology Program of Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
  • Hung AY; Center for Advanced Parkinson Research, Harvard Medical School, Brigham and Women's Hospital, Boston, MA, USA.
  • Schwarzschild MA; Precision Neurology Program of Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
  • Hayes MT; The Norwegian Centre for Movement Disorders, Stavanger University Hospital, Stavanger, Norway.
  • Wills AM; Department of Chemistry, Bioscience and Environmental Engineering, University of Stavanger, Stavanger, Norway.
  • Herrington TM; Departments of Neurology and Radiology, Washington University School of Medicine, St. Louis, MO, USA.
  • Ravina B; Paris-Saclay University, Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Inserm, Gustave Roussy, 'Exposome and heredity' team, Centre de researche en épidémiologie et santé des populations (CESP), Villejuif, France.
  • Shoulson I; Sorbonne Université, Paris Brain Institute - Institut du Cerveau - ICM, Institut National de Santé et en Recherche Médicale, Centre National de Recherche Scientifique, Assistance Publique Hôpitaux de Paris, Département de Neurologie et de Génétique, Centre d'Investigation Clinique Neurosciences, Hôp
  • Taba P; Sorbonne Université, Paris Brain Institute - Institut du Cerveau - ICM, Institut National de Santé et en Recherche Médicale, Centre National de Recherche Scientifique, Assistance Publique Hôpitaux de Paris, Département de Neurologie et de Génétique, Centre d'Investigation Clinique Neurosciences, Hôp
  • Kõks S; Sorbonne Université, Paris Brain Institute - Institut du Cerveau - ICM, Institut National de Santé et en Recherche Médicale, Centre National de Recherche Scientifique, Assistance Publique Hôpitaux de Paris, Département de Neurologie et de Génétique, Centre d'Investigation Clinique Neurosciences, Hôp
  • Beach TG; Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
  • Cormier-Dequaire F; Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
  • Alves G; Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
  • Tysnes OB; Center for Advanced Parkinson Research, Harvard Medical School, Brigham and Women's Hospital, Boston, MA, USA.
  • Perlmutter JS; Department of Neurology, Brigham and Women's Hospital, Boston, MA, USA.
  • Heutink P; Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
  • Amr SS; Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
  • van Hilten JJ; Praxis Precision Medicines, Cambridge, MA, USA.
  • Kasten M; Department of Neurology, Center for Health + Technology, University of Rochester, Rochester, NY, USA.
  • Mollenhauer B; Department of Neurology and Neurosurgery, University of Tartu, Tartu, Estonia.
  • Trenkwalder C; Centre for Molecular Medicine and Innovative Therapeutics, Murdoch University, Perth, Western Australia, Australia.
  • Klein C; Perron Institute for Neurological and Translational Science, Perth, Western Australia, Australia.
  • Barker RA; Banner Sun Health Research Institute, Sun City, AZ, USA.
  • Williams-Gray CH; Sorbonne Université, Paris Brain Institute - Institut du Cerveau - ICM, Institut National de Santé et en Recherche Médicale, Centre National de Recherche Scientifique, Assistance Publique Hôpitaux de Paris, Département de Neurologie et de Génétique, Centre d'Investigation Clinique Neurosciences, Hôp
  • Marinus J; The Norwegian Centre for Movement Disorders, Stavanger University Hospital, Stavanger, Norway.
  • Scherzer CR; Department of Neurology, Stavanger University Hospital, Stavanger, Norway.
Nat Genet ; 53(6): 787-793, 2021 06.
Article en En | MEDLINE | ID: mdl-33958783
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Enfermedad de Parkinson / Sinapsis / Cognición / Progresión de la Enfermedad / Herencia Multifactorial / Estudio de Asociación del Genoma Completo / Sitios Genéticos Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Año: 2021 Tipo del documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Enfermedad de Parkinson / Sinapsis / Cognición / Progresión de la Enfermedad / Herencia Multifactorial / Estudio de Asociación del Genoma Completo / Sitios Genéticos Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Año: 2021 Tipo del documento: Article