The antibacterial activity of peptide dendrimers and polymyxin B increases sharply above pH 7.4.
Chem Commun (Camb)
; 57(46): 5654-5657, 2021 Jun 08.
Article
en En
| MEDLINE
| ID: mdl-33972964
ABSTRACT
pH-activity profiling reveals that antimicrobial peptide dendrimers (AMPDs) kill Klebsiella pneumoniae and Methicillin-resistant Staphylococcus aureus (MRSA) at pH = 8.0, against which they are inactive at pH = 7.4, due to stronger electrostatic binding to bacterial cells at higher pH. A similar effect occurs with polymyxin B and might be general for polycationic antimicrobials.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Péptidos
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Polimixina B
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Dendrímeros
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Staphylococcus aureus Resistente a Meticilina
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Klebsiella pneumoniae
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Antibacterianos
Idioma:
En
Año:
2021
Tipo del documento:
Article