Gm40600 promotes CD4+ T-cell responses by interacting with Ahnak.
Immunology
; 164(1): 190-206, 2021 09.
Article
en En
| MEDLINE
| ID: mdl-33987830
ABSTRACT
It is important to characterize novel proteins involved in T- and B-cell responses. Our previous study demonstrated that a novel protein, Mus musculus Gm40600, reduced the proliferation of Mus musculus plasmablast (PB)-like SP 2/0 cells and B-cell responses induced in vitro by LPS. In the present study, we revealed that Gm40600 directly promoted CD4+ T-cell responses to indirectly up-regulate B-cell responses. Importantly, we found that CD4+ T-cell responses, including T-cell activation and differentiation and cytokine production, were increased in Gm40600 transgenic (Tg) mice and were reduced in Gm40600 knockout (KO) mice. Finally, we demonstrated that Gm40600 promoted the Ahnak-mediated calcium signalling pathway by interacting with Ahnak to maintain a cytoplasmic lateral location of Ahnak in CD4+ T cells. Collectively, our data suggest that Gm40600 promotes CD4+ T-cell activation to up-regulate the B-cell response via interacting with Ahnak to promote the calcium signalling pathway. The results suggest that targeting Gm40600 may be a means to control CD4+ T-cell-related diseases.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Linfocitos B
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Linfocitos T CD4-Positivos
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Virus de la Leucemia Murina
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Péptidos y Proteínas de Señalización Intracelular
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Proteínas de la Membrana
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Proteínas de Neoplasias
Límite:
Animals
Idioma:
En
Año:
2021
Tipo del documento:
Article