Clinical and Demographic Characteristics of Cutaneous Mastocytosis in Childhood: Single-center Experience.
J Pediatr Hematol Oncol
; 44(1): e227-e232, 2022 01 01.
Article
en En
| MEDLINE
| ID: mdl-34001789
ABSTRACT
INTRODUCTION:
Mastocytosis is a rare and heterogenous disease, and in children it is generally limited to the skin and tends to regress spontaneously in adolescence.AIM:
In this study, demographic, clinical, and laboratory characteristics of pediatric patients with mastocytosis, and also coexisting diseases were investigated.RESULTS:
A total of 61 pediatric patients were included in the study. The male-to-female ratio was 2.2, the median age was 2 years (range, 0.25 to 19 y), and the median follow-up period was 2.0 years (range, 0.25 to 19 y). Types of clinical presentation at diagnosis consisted of mainly urticaria pigmentosa (45.9%). Seven patients were further investigated with suspicion of systemic mastocytosis, they were followed up, median of 9 years (range, 2.5 to 16 y), and none of them developed systemic disease. Coexisting allergic diseases were recorded in total 5 patients (8.2%). Three patients had immunoglobulin A deficiency, 1 patient had elevated immunoglobulin E level. A patient developed mature B-cell lymphoma with a heterozygous mutation in c-KIT exon 11.DISCUSSION:
Cutaneous mastocytosis in children may present as a complex disease with different clinical signs and symptoms. Standardized clinical criteria and guidelines for the follow-up of children with mastocytosis are required.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Urticaria Pigmentosa
Tipo de estudio:
Guideline
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Observational_studies
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Prognostic_studies
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Qualitative_research
Límite:
Adolescent
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Adult
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Child
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Child, preschool
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Female
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Humans
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Infant
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Male
Idioma:
En
Año:
2022
Tipo del documento:
Article