Yap regulates skeletal muscle fatty acid oxidation and adiposity in metabolic disease.
Nat Commun
; 12(1): 2887, 2021 05 17.
Article
en En
| MEDLINE
| ID: mdl-34001905
ABSTRACT
Obesity is a major risk factor underlying the development of metabolic disease and a growing public health concern globally. Strategies to promote skeletal muscle metabolism can be effective to limit the progression of metabolic disease. Here, we demonstrate that the levels of the Hippo pathway transcriptional co-activator YAP are decreased in muscle biopsies from obese, insulin-resistant humans and mice. Targeted disruption of Yap in adult skeletal muscle resulted in incomplete oxidation of fatty acids and lipotoxicity. Integrated 'omics analysis from isolated adult muscle nuclei revealed that Yap regulates a transcriptional profile associated with metabolic substrate utilisation. In line with these findings, increasing Yap abundance in the striated muscle of obese (db/db) mice enhanced energy expenditure and attenuated adiposity. Our results demonstrate a vital role for Yap as a mediator of skeletal muscle metabolism. Strategies to enhance Yap activity in skeletal muscle warrant consideration as part of comprehensive approaches to treat metabolic disease.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Músculo Esquelético
/
Proteínas Adaptadoras Transductoras de Señales
/
Adiposidad
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Ácidos Grasos
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Enfermedades Metabólicas
Tipo de estudio:
Risk_factors_studies
Límite:
Animals
Idioma:
En
Año:
2021
Tipo del documento:
Article