Efficacy and safety of opioid therapy guided by pharmacogenetics: a systematic review.
Pharmacogenomics
; 22(9): 573-586, 2021 06.
Article
en En
| MEDLINE
| ID: mdl-34013775
ABSTRACT
Aim:
To perform a systematic review to determine the efficacy/safety of PGx-guided opioid therapy for chronic/postoperative pain. Materials &methods:
We searched PubMed and other specialized databases. Articles were considered if they compared the efficacy/safety of PGx-guided opioid therapy versus usual care. The risk of bias assessment was performed using Cochrane tools.Results:
A total of 3794 records were retrieved. Only five were included for data extraction. A lower requirement of analgesics during postoperative in the PGx-guided intervention arm was reported in two studies. Also, two studies reported significant pain improvement in favor of the PGx-guided therapy when analyzing the subgroup of patients with a high-risk CYP2D6 phenotype.Conclusion:
Despite the findings described, information on the efficacy/safety of this intervention is scarce.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Manejo del Dolor
/
Pruebas de Farmacogenómica
/
Analgésicos Opioides
Tipo de estudio:
Systematic_reviews
Límite:
Humans
Idioma:
En
Año:
2021
Tipo del documento:
Article