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HLA-DRB1*15:01 is a co-receptor for Epstein-Barr virus, linking genetic and environmental risk factors for multiple sclerosis.
Menegatti, Jennifer; Schub, David; Schäfer, Marco; Grässer, Friedrich A; Ruprecht, Klemens.
  • Menegatti J; Institute for Virology, Gebäude 47, Universität des Saarlandes, Homburg, Germany.
  • Schub D; Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Neurology, Berlin, Germany.
  • Schäfer M; Department of Transplant and Infection Immunology, Gebäude 47, Universität des Saarlandes, Homburg, Germany.
  • Grässer FA; HLA Laboratory, Stefan-Morsch-Stiftung, Birkenfeld, Germany.
  • Ruprecht K; Institute for Virology, Gebäude 47, Universität des Saarlandes, Homburg, Germany.
Eur J Immunol ; 51(9): 2348-2350, 2021 09.
Article en En | MEDLINE | ID: mdl-34019695
ABSTRACT
The strongest genetic and environmental risk factors for MS, an inflammatory CNS disease, are HLA-DRB1*1501 and EBV. This work shows that HLA-DRB1*1501 acts as a co-receptor for EBV infection of a B cell line, suggesting a mechanistic link between both risk factors for MS.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Receptores Virales / Herpesvirus Humano 4 / Cadenas HLA-DRB1 / Esclerosis Múltiple Tipo de estudio: Etiology_studies / Risk_factors_studies Límite: Humans Idioma: En Año: 2021 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Receptores Virales / Herpesvirus Humano 4 / Cadenas HLA-DRB1 / Esclerosis Múltiple Tipo de estudio: Etiology_studies / Risk_factors_studies Límite: Humans Idioma: En Año: 2021 Tipo del documento: Article