EMA401, an angiotensin II type 2 receptor antagonist blocks visceral hypersensitivity and colonic hyperpermeability in rat model of irritable bowel syndrome.
J Pharmacol Sci
; 146(3): 121-124, 2021 Jul.
Article
en En
| MEDLINE
| ID: mdl-34030794
ABSTRACT
Visceral hypersensitivity and impaired gut barrier are crucial pathophysiology of irritable bowel syndrome (IBS), and injection of lipopolysaccharide or corticotropin-releasing factor, and repeated water avoidance stress simulate these gastrointestinal changes in rat (IBS models). We previously demonstrated that losartan, an angiotensin II type 1 (AT1) receptor antagonist prevented these changes, and we attempted to determine the effects of EMA401, an AT2 receptor antagonist in the current study. EMA401 blocked visceral hypersensitivity and colonic hyperpermeability in these models, and naloxone reversed the effects by EMA401. These results suggest that EMA401 may improve gut function via opioid signaling in IBS.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Permeabilidad
/
Compuestos de Bencidrilo
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Colon
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Síndrome del Colon Irritable
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Bloqueadores del Receptor Tipo 2 de Angiotensina II
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Dolor Visceral
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Hiperalgesia
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Isoquinolinas
Tipo de estudio:
Etiology_studies
/
Prognostic_studies
Límite:
Animals
Idioma:
En
Año:
2021
Tipo del documento:
Article