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Furmonertinib (Alflutinib, AST2818) is a potential positive control drug comparable to rifampin for evaluation of CYP3A4 induction in sandwich-cultured primary human hepatocytes.
Wu, Ya-Li; Xue, Ya-Ru; Guo, Zi-Tao; Chen, Zhen-Dong; Ge, Xin-Yu; Zhong, Da-Fang; Diao, Xing-Xing.
  • Wu YL; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201210, China.
  • Xue YR; University of Chinese Academy of Sciences, Beijing, 100049, China.
  • Guo ZT; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201210, China.
  • Chen ZD; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201210, China.
  • Ge XY; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201210, China.
  • Zhong DF; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201210, China.
  • Diao XX; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201210, China. dfzhong@simm.ac.cn.
Acta Pharmacol Sin ; 43(3): 747-756, 2022 Mar.
Article en En | MEDLINE | ID: mdl-34035488
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Piridinas / Pirimidinas / Rifampin / Hepatocitos / Inductores del Citocromo P-450 CYP3A / Indoles Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Año: 2022 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Piridinas / Pirimidinas / Rifampin / Hepatocitos / Inductores del Citocromo P-450 CYP3A / Indoles Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Año: 2022 Tipo del documento: Article