Immune evasion of SARS-CoV-2 variants of concern is driven by low affinity to neutralizing antibodies.
Chem Commun (Camb)
; 57(49): 6094-6097, 2021 Jun 21.
Article
en En
| MEDLINE
| ID: mdl-34037640
ABSTRACT
SARS-CoV-2 VOC immune evasion is mainly due to lower cross-reactivity from previously elicited class I/II neutralizing antibodies, while increased affinity to hACE2 plays a minor role. The affinity between antibodies and VOCs is impacted by remodeling of the electrostatic surface potential of the Spike RBDs. The P.3 variant is a putative VOC.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Anticuerpos Neutralizantes
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Evasión Inmune
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SARS-CoV-2
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Afinidad de Anticuerpos
Idioma:
En
Año:
2021
Tipo del documento:
Article