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Effects of N-terminus modified Hx-amides on DNA binding affinity, sequence specificity, cellular uptake, and gene expression.
Kiakos, Konstantinos; Satam, Vijay; Patil, Pravin C; Sweers, Jeffrey; Bowerman, Michael; Tzou, Sam; Olsen, Kevin; Lee, Megan; Schaschl, Helmut; Keppler, Bernhard K; Hochhauser, Daniel; Lee, Moses; Hartley, John A; Pett, Luke.
  • Kiakos K; Cancer Research UK Drug-DNA Interactions Research Group, UCL Cancer Institute, London WC1E 6BT, United Kingdom; Institute of Inorganic Chemistry, Faculty of Chemistry, University of Vienna, Waehringer Str. 42, 1090 Vienna, Austria. Electronic address: konstantinos.kiakos@univie.ac.at.
  • Satam V; Department of Chemistry, Hope College, Holland, MI 49422, USA.
  • Patil PC; Department of Chemistry, Hope College, Holland, MI 49422, USA.
  • Sweers J; Department of Chemistry, Hope College, Holland, MI 49422, USA.
  • Bowerman M; Department of Chemistry, Hope College, Holland, MI 49422, USA.
  • Tzou S; Department of Chemistry, Hope College, Holland, MI 49422, USA.
  • Olsen K; Department of Chemistry, Hope College, Holland, MI 49422, USA.
  • Lee M; Department of Chemistry, Hope College, Holland, MI 49422, USA.
  • Schaschl H; Department of Evolutionary Anthropology, Faculty of Life Sciences, University of Vienna, Althanstrasse 14, 1090 Vienna, Austria.
  • Keppler BK; Institute of Inorganic Chemistry, Faculty of Chemistry, University of Vienna, Waehringer Str. 42, 1090 Vienna, Austria.
  • Hochhauser D; Cancer Research UK Drug-DNA Interactions Research Group, UCL Cancer Institute, London WC1E 6BT, United Kingdom.
  • Lee M; Department of Chemistry, Hope College, Holland, MI 49422, USA; Department of Chemistry, Georgia State University, Atlanta, GA 30303, USA.
  • Hartley JA; Cancer Research UK Drug-DNA Interactions Research Group, UCL Cancer Institute, London WC1E 6BT, United Kingdom.
  • Pett L; Cancer Research UK Drug-DNA Interactions Research Group, UCL Cancer Institute, London WC1E 6BT, United Kingdom.
Bioorg Med Chem Lett ; 47: 128158, 2021 09 01.
Article en En | MEDLINE | ID: mdl-34058343
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: ADN de Neoplasias / ADN-Topoisomerasas de Tipo II / Proteínas de Unión a Poli-ADP-Ribosa / Amidas Límite: Humans Idioma: En Año: 2021 Tipo del documento: Article
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: ADN de Neoplasias / ADN-Topoisomerasas de Tipo II / Proteínas de Unión a Poli-ADP-Ribosa / Amidas Límite: Humans Idioma: En Año: 2021 Tipo del documento: Article