δ-Catenin Participates in EGF/AKT/p21Waf Signaling and Induces Prostate Cancer Cell Proliferation and Invasion.
Int J Mol Sci
; 22(10)2021 May 18.
Article
en En
| MEDLINE
| ID: mdl-34069970
ABSTRACT
Prostate cancer (PCa) is the second most leading cause of death in males. Our previous studies have demonstrated that δ-catenin plays an important role in prostate cancer progression. However, the molecular mechanism underlying the regulation of δ-catenin has not been fully explored yet. In the present study, we found that δ-catenin could induce phosphorylation of p21Waf and stabilize p21 in the cytoplasm, thus blocking its nuclear accumulation for the first time. We also found that δ-catenin could regulate the interaction between AKT and p21, leading to phosphorylation of p21 at Thr-145 residue. Finally, EGF was found to be a key factor upstream of AKT/δ-catenin/p21 for promoting proliferation and metastasis in prostate cancer. Our findings provide new insights into molecular controls of EGF and the development of potential therapeutics targeting δ-catenin to control prostate cancer progression.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Neoplasias de la Próstata
/
Factor de Crecimiento Epidérmico
/
Proteínas Proto-Oncogénicas c-akt
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Inhibidor p21 de las Quinasas Dependientes de la Ciclina
/
Cateninas
Tipo de estudio:
Prognostic_studies
Límite:
Humans
/
Male
Idioma:
En
Año:
2021
Tipo del documento:
Article