Farnesol induces protection against murine CNS inflammatory demyelination and modifies gut microbiome.
Clin Immunol
; 235: 108766, 2022 02.
Article
en En
| MEDLINE
| ID: mdl-34091018
ABSTRACT
Farnesol is a 15carbon organic isoprenol synthesized by plants and mammals with anti-oxidant, anti-inflammatory, and neuroprotective activities. We sought to determine whether farnesol treatment would result in protection against murine experimental autoimmune encephalomyelitis (EAE), a well-established model of multiple sclerosis (MS). We compared disease progression and severity in C57BL/6 mice treated orally with 100 mg/kg/day farnesol solubilized in corn oil to corn-oil treated and untreated EAE mice. Farnesol significantly delayed the onset of EAE (by ~2 days) and dramatically decreased disease severity (~80%) compared to controls. Disease protection by farnesol was associated with a significant reduction in spinal cord infiltration by monocytes-macrophages, dendritic cells, CD4+ T cells, and a significant change in gut microbiota composition, including a decrease in the FirmicutesBacteroidetes ratio. The study suggests FOL could protect MS patients against CNS inflammatory demyelination by partially modulating the gut microbiome composition.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Encefalomielitis Autoinmune Experimental
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Farnesol
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Microbioma Gastrointestinal
Límite:
Animals
Idioma:
En
Año:
2022
Tipo del documento:
Article