3-MST, 3-mercaptopyruvate sulfurtransferase; AMPK, adenosine 5'-monophosphate-activated protein kinase; Antitumor effect; BCL-2, B-cell lymphoma-2; BITC, benzyl isothiocyanate; BRCA2, breast cancer 2; CAT, cysteine aminotransferase; CBS, cystathionine-ß-synthase; CDC25B, cell division cycle 25B; CDK1, cyclin-dependent kinase 1; CHK2, checkpoint kinase 2; CSE, cystathionine-γ-lyase; Cell proliferation; DATS, diallyl trisulfide; DR4, death receptor; EMT, epithelial­mesenchymal transition; ERK1/2, extracellular signal-regulated kinase; ERU, erucin; FOXM1, forkhead box protein M1; GLUTs, glucose transporters; H2S, hydrogen sulfide; HDAC, histone deacetylase; HEATR1, human HEAT repeat-containing protein 1; HIF-1α, hypoxia inducible factor; Hydrogen sulfide donor; ITCs, isothiocyanates; JNK, c-Jun N-terminal kinase; KEAP1‒NRF2‒ARE, the recombinant protein 1-nuclear factor erythroid-2 related factor 2-antioxidant response element; KRAS, kirsten rat sarcoma viral oncogene; NF-κB, nuclear factor kappa B; NO, nitric oxide; OCT-4, octamer-binding transcription factor 4; P16, multiple tumor suppressor 1; PARP, poly(ADP-ribose)-polymerase; PDGFRα, platelet-derived growth factor receptor; PEITC, phenethyl isothiocyanate; PI3K/AKT, phosphoinositide 3-kinase/v-AKT murine thymoma viral oncogene; Pancreatic cancer; RASAL2, RAS protein activator like 2; ROS, reactive oxygen species; RPL10, human ribosomal protein L10; SFN, sulforaphane; SHH, sonic hedgehog; SMAD4, mothers against decapentaplegic homolog 4; STAT-3, signal transducer and activator of transcription 3; Signaling pathway; Sulfur-containing compound; TRAIL, The human tumor necrosis factor-related apoptosis-inducing ligand; VEGF, vascular endothelial growth factor; XIAP, X-linked inhibitor of apoptosis protein; ZEB1, zinc finger E box-binding protein-1; iNOS, inducible nitric oxide synthase