RADX prevents genome instability by confining replication fork reversal to stalled forks.

Krishnamoorthy, Archana; Jackson, Jessica; Mohamed, Taha; Adolph, Madison; Vindigni, Alessandro; Cortez, David

Krishnamoorthy, Archana; Jackson, Jessica; Mohamed, Taha; Adolph, Madison; Vindigni, Alessandro; Cortez, David.

Krishnamoorthy A; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37237, USA.
Jackson J; Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
Mohamed T; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37237, USA.
Adolph M; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37237, USA.
Vindigni A; Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
Cortez D; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37237, USA. Electronic address: david.cortez@vanderbilt.edu.

Mol Cell ; 81(14): 3007-3017.e5, 2021 07 15.

Article en En | MEDLINE | ID: mdl-34107305

Asunto(s)

Replicación del ADN/genética; Proteínas de Unión al ADN/genética; Inestabilidad Genómica/genética; Origen de Réplica/genética; Línea Celular; Línea Celular Tumoral; Roturas del ADN de Doble Cadena; ADN Helicasas/genética; Reparación del ADN/genética; ADN de Cadena Simple/genética; Células HEK293; Células HeLa; Humanos; Unión Proteica/genética; Recombinasa Rad51/genética

Palabras clave

BRCA2; DNA damage; DNA repair; DNA replication; electron microscopy; genome instability; telomere

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Origen de Réplica / Inestabilidad Genómica / Proteínas de Unión al ADN / Replicación del ADN Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Año: 2021 Tipo del documento: Article

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