Arteriopathy in pediatric stroke: an underestimated clinical entity.
Arq Neuropsiquiatr
; 79(4): 321-333, 2021 04.
Article
en En
| MEDLINE
| ID: mdl-34133513
ABSTRACT
BACKGROUND:
Pediatric arterial ischemic stroke (AIS), which was thought to be a rare disorder, is being increasingly recognized as an important cause of neurological morbidity, thanks to new advances in neuroimaging.OBJECTIVE:
The aim of this study was to review the main etiologies of stroke due to arteriopathy in children.METHODS:
Using a series of cases from our institution, we addressed its epidemiological aspects, physiopathology, imaging findings from CT, MR angiography, MR conventional sequences and MR DWI, and nuclear medicine findings.RESULTS:
Through discussion of the most recent classification for childhood AIS (Childhood AIS Standardized Classification and Diagnostic Evaluation, CASCADE), we propose a modified classification based on the anatomical site of disease, which includes vasculitis, varicella, arterial dissection, moyamoya, fibromuscular dysplasia, Takayasu's arteritis and genetic causes (such as ACTA-2 mutation, PHACE syndrome and ADA-2 deficiency). We have detailed each of these separately.Conclusions:
Prompt recognition of AIS and thorough investigation for potential risk factors are crucial for a better outcome. In this scenario, neurovascular imaging plays an important role in diagnosing AIS and identifying children at high risk of recurrent stroke.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Enfermedades Arteriales Cerebrales
/
Isquemia Encefálica
/
Accidente Cerebrovascular
Tipo de estudio:
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Child
/
Humans
Idioma:
En
Año:
2021
Tipo del documento:
Article