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Transient developmental imbalance of cortical interneuron subtypes presages long-term changes in behavior.
Magno, Lorenza; Asgarian, Zeinab; Pendolino, Valentina; Velona, Theodora; Mackintosh, Albert; Lee, Flora; Stryjewska, Agata; Zimmer, Celine; Guillemot, François; Farrant, Mark; Clark, Beverley; Kessaris, Nicoletta.
  • Magno L; Wolfson Institute for Biomedical Research, University College London, Gower Street, London WC1E 6BT, UK; Department of Cell and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK.
  • Asgarian Z; Wolfson Institute for Biomedical Research, University College London, Gower Street, London WC1E 6BT, UK; Department of Cell and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK.
  • Pendolino V; Department of Neuroscience, Physiology and Pharmacology, University College London, Gower Street, London WC1E 6BT, UK.
  • Velona T; Wolfson Institute for Biomedical Research, University College London, Gower Street, London WC1E 6BT, UK.
  • Mackintosh A; Wolfson Institute for Biomedical Research, University College London, Gower Street, London WC1E 6BT, UK.
  • Lee F; Wolfson Institute for Biomedical Research, University College London, Gower Street, London WC1E 6BT, UK.
  • Stryjewska A; Wolfson Institute for Biomedical Research, University College London, Gower Street, London WC1E 6BT, UK; Department of Cell and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK.
  • Zimmer C; The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.
  • Guillemot F; The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.
  • Farrant M; Department of Neuroscience, Physiology and Pharmacology, University College London, Gower Street, London WC1E 6BT, UK.
  • Clark B; Wolfson Institute for Biomedical Research, University College London, Gower Street, London WC1E 6BT, UK; Department of Neuroscience, Physiology and Pharmacology, University College London, Gower Street, London WC1E 6BT, UK.
  • Kessaris N; Wolfson Institute for Biomedical Research, University College London, Gower Street, London WC1E 6BT, UK; Department of Cell and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK. Electronic address: n.kessaris@ucl.ac.uk.
Cell Rep ; 35(11): 109249, 2021 06 15.
Article en En | MEDLINE | ID: mdl-34133916
Cortical GABAergic interneurons are generated in large numbers in the ganglionic eminences and migrate into the cerebral cortex during embryogenesis. At early postnatal stages, during neuronal circuit maturation, autonomous and activity-dependent mechanisms operate within the cortex to adjust cell numbers by eliminating naturally occurring neuron excess. Here, we show that when cortical interneurons are generated in aberrantly high numbers-due to a defect in precursor cell proliferation during embryogenesis-extra parvalbumin interneurons persist in the postnatal mouse cortex during critical periods of cortical network maturation. Even though cell numbers are subsequently normalized, behavioral abnormalities remain in adulthood. This suggests that timely clearance of excess cortical interneurons is critical for correct functional maturation of circuits that drive adult behavior.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Conducta Animal / Corteza Cerebral / Interneuronas Límite: Animals Idioma: En Año: 2021 Tipo del documento: Article
Texto completo
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Conducta Animal / Corteza Cerebral / Interneuronas Límite: Animals Idioma: En Año: 2021 Tipo del documento: Article