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A cancer mutation promotes EphA4 oligomerization and signaling by altering the conformation of the SAM domain.
Light, Taylor P; Gomez-Soler, Maricel; Wang, Zichen; Karl, Kelly; Zapata-Mercado, Elmer; Gehring, Marina P; Lechtenberg, Bernhard C; Pogorelov, Taras V; Hristova, Kalina; Pasquale, Elena B.
  • Light TP; Department of Materials Science and Engineering, Institute for NanoBioTechnology, Johns Hopkins University, Baltimore, Maryland, USA.
  • Gomez-Soler M; Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California, USA.
  • Wang Z; Department of Chemistry, Center for Biophysics and Quantitative Biology, Beckman Institute for Advanced Science and Technology, and National Center for Supercomputing Applications, School of Chemical Sciences, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.
  • Karl K; Program in Molecular Biophysics, Institute for NanoBioTechnology, Johns Hopkins University, Baltimore, Maryland, USA.
  • Zapata-Mercado E; Program in Molecular Biophysics, Institute for NanoBioTechnology, Johns Hopkins University, Baltimore, Maryland, USA.
  • Gehring MP; Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California, USA.
  • Lechtenberg BC; Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California, USA.
  • Pogorelov TV; Department of Chemistry, Center for Biophysics and Quantitative Biology, Beckman Institute for Advanced Science and Technology, and National Center for Supercomputing Applications, School of Chemical Sciences, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.
  • Hristova K; Department of Materials Science and Engineering, Institute for NanoBioTechnology, Johns Hopkins University, Baltimore, Maryland, USA; Program in Molecular Biophysics, Institute for NanoBioTechnology, Johns Hopkins University, Baltimore, Maryland, USA. Electronic address: kalina.hristova@jhu.edu.
  • Pasquale EB; Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California, USA. Electronic address: elenap@sbpdiscovery.org.
J Biol Chem ; 297(1): 100876, 2021 07.
Article en En | MEDLINE | ID: mdl-34139238
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Transducción de Señal / Mutación Missense / Receptor EphA4 / Motivo alfa Estéril / Neoplasias Límite: Humans Idioma: En Año: 2021 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Transducción de Señal / Mutación Missense / Receptor EphA4 / Motivo alfa Estéril / Neoplasias Límite: Humans Idioma: En Año: 2021 Tipo del documento: Article