Therapeutic options in inoperable ROS1-rearranged inflammatory myofibroblastic tumor of the tongue in a child: a case report and literature review.
Anticancer Drugs
; 32(10): 1111-1115, 2021 11 01.
Article
en En
| MEDLINE
| ID: mdl-34145176
ABSTRACT
Inflammatory myofibroblastic tumor (IMT) is a rare borderline malignancy, usually treated with surgery only. Exceedingly rare cases of inoperable, recurrent, or metastatic IMTs pose a therapeutic challenge. We report successful treatment of a 7-year-old girl with an inoperable anaplastic lymphoma kinase (ALK)-negative IMT of the tongue. The patient underwent various anti-inflammatory (steroids, nonsteroidal anti-inflammatory drugs, clarithromycin) and antiproliferative (chemotherapy) therapies to enable tumor regression and complete resection. Ultimately, next-generation sequencing of the tumor revealed a TFG-ROS-1 translocation, allowing for an off-label targeted therapy with crizotinib. Crizotinib treatment caused slight tumor regression but evident change of its structure, allowing for complete non-mutilating resection. Two histopathology examinations revealed complete disappearance of neoplastic cells following therapy. The patient remains disease-free 22 months after the delayed surgery. In children with inoperable ALK-negative IMTs, molecular testing must be performed to identify other targetable oncogenic fusions, including TFG-ROS1.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Neoplasias de la Lengua
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Crizotinib
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Neoplasias de Tejido Muscular
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Antineoplásicos
Tipo de estudio:
Prognostic_studies
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Systematic_reviews
Límite:
Child
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Female
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Humans
Idioma:
En
Año:
2021
Tipo del documento:
Article