Circadian rhythms in cardiac metabolic flexibility.
Chronobiol Int
; 40(1): 13-26, 2023 01.
Article
en En
| MEDLINE
| ID: mdl-34162286
ABSTRACT
Numerous aspects of cardiovascular physiology (e.g., heart rate, blood pressure) and pathology (e.g., myocardial infarction and sudden cardiac death) exhibit time-of-day-dependency. In association with day-night differences in energetic demand and substrate availability, the healthy heart displays remarkable metabolic flexibility through temporal partitioning of the metabolic fate of common substrates (glucose, lipid, amino acids). The purpose of this review is to highlight the contribution that circadian clocks provide toward 24-hr fluctuations in cardiac metabolism and to discuss whether attenuation and/or augmentation of these metabolic rhythms through adjustment of nutrient intake timing impacts cardiovascular disease development.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Relojes Circadianos
/
Infarto del Miocardio
Límite:
Humans
Idioma:
En
Año:
2023
Tipo del documento:
Article