Discovery of eudesmane-type sesquiterpenoids with neuroprotective effects from the roots of Chloranthus serratus.
Fitoterapia
; 153: 104971, 2021 Sep.
Article
en En
| MEDLINE
| ID: mdl-34166705
ABSTRACT
Seven eudesmane-type sesquiterpenoids, including three pairs of racemic compounds (1a-3a and 1b-3b) and a sesquiterpenoid lactone (4), were obtained from the roots of Chloranthus serratus. The structures of these sesquiterpenoids were characterized based on spectroscopic analyses, ECD calculations, and X-ray diffraction experiment. Neuroprotection assays of the isolated eudesmane-type sesquiterpenoids were conducted on H2O2 damaged PC12 cells. At the concentration of 10 µM, compounds 1b and 4 increased cell viability from 54.8 ± 3.3% to 76.8 ± 2.3 and 72.7 ± 8.2%, respectively.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Fármacos Neuroprotectores
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Magnoliopsida
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Sesquiterpenos de Eudesmano
Límite:
Animals
País como asunto:
Asia
Idioma:
En
Año:
2021
Tipo del documento:
Article