Can remdesivir and its parent nucleoside GS-441524 be potential oral drugs? An <i>in vitro</i> and <i>in vivo</i> DMPK assessment.

Can remdesivir and its parent nucleoside GS-441524 be potential oral drugs? An in vitro and in vivo DMPK assessment.

Xie, Jiashu; Wang, Zhengqiang.

Xie J; Center for Drug Design, College of Pharmacy, University of Minnesota, Minneapolis, MN 55455, USA.
Wang Z; Center for Drug Design, College of Pharmacy, University of Minnesota, Minneapolis, MN 55455, USA.

Acta Pharm Sin B ; 11(6): 1607-1616, 2021 Jun.

Article en En | MEDLINE | ID: mdl-34221871

Palabras clave

ADK, adenosine kinase; Antiviral; COVID-19; CYP, cytochrome P450; Cobi, cobicistat; DMPK, drug metabolism and pharmacokinetics; Drug metabolism; EMS, enhanced mass scan; EPI, enhanced product ion; FIPV, feline infectious peritonitis coronavirus; GS-441524; HINTs, histidine triad nucleotide binding proteins; HLMs, human liver microsomes; IDA, information dependent acquisition; MLMs, mouse liver microsomes; MRM, multiple reaction monitoring; Nucleoside; Oral bioavailability; RDV, remdesivir; RdRp, RNA-dependent RNA-polymerases; Remdesivir; SARS-CoV-2; SOF, sofosbuvir; TAF, tenofovir alafenamide

Texto completo: 1 Banco de datos: MEDLINE Idioma: En Año: 2021 Tipo del documento: Article

Texto completo: 1 Banco de datos: MEDLINE Idioma: En Año: 2021 Tipo del documento: Article