Wheat bran with reduced particle size increases serum SCFAs in obese subjects without improving health parameters compared with a maltodextrin placebo.
Am J Clin Nutr
; 114(4): 1328-1341, 2021 10 04.
Article
en En
| MEDLINE
| ID: mdl-34224554
ABSTRACT
BACKGROUND:
Wheat bran (WB) has been associated with improved gastrointestinal health and a reduced risk of metabolic disorders. Reducing the particle size of WB might increase its fermentability and facilitate cross-feeding between the gut bacteria and in this way produce health effects.OBJECTIVES:
We investigated the impact of WB with reduced particle size (WB RPS) on colonic fermentation and host health in normal-weight (NW) and obese (OB) participants compared with placebo (PL).METHODS:
During 1 mo, 36 NW and 14 OB participants daily consumed 20 g WB RPS or PL (maltodextrin). Before and after the intervention, fasting serum and fecal SCFAs, fecal metabolite profiles, and microbiota composition were measured as fermentation parameters. Fecal output, fecal dry weight (%), fat excretion, transit, stool consistency, intestinal permeability, and serum total cholesterol, triglyceride, and C-reactive protein concentrations were measured as health parameters. The impact of WB RPS on the fermentation of other carbohydrates was assessed by quantifying postprandial cumulative serum 13C-SCFA after a challenge with 13C-inulin.RESULTS:
WB RPS increased fasting serum acetate (P < 0.05) and total SCFA (P < 0.05) concentrations in OB participants. Fasting serum propionate concentrations were lower in OB than in NW participants at baseline (NW 1.57 ± 0.75 µmol/L; OB 0.89 ± 0.52 µmol/L; P < 0.01), but not after WB RPS (NW 1.75 ± 0.77 µmol/L; OB 1.35 ± 0.63 µmol/L; P = not significant). WB RPS did not enhance colonic fermentation of 13C-inulin and did not affect microbiota composition. Health parameters were not affected by the WB RPS intervention, either in NW or in OB participants.CONCLUSIONS:
WB RPS increased fasting serum SCFA concentrations in OB participants. These changes were not associated with beneficial effects on host health.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Tamaño de la Partícula
/
Polisacáridos
/
Fibras de la Dieta
/
Ácidos Grasos Volátiles
Tipo de estudio:
Clinical_trials
/
Observational_studies
/
Risk_factors_studies
Límite:
Adolescent
/
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Año:
2021
Tipo del documento:
Article