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Autophagy in vascular dementia and natural products with autophagy regulating activity.
Wang, Wenzhe; Qiao, Ou; Ji, Haixia; Zhang, Xinyu; Han, Xiaoying; Zhang, Yi; Wang, Juan; Li, Xia; Gao, Wenyuan.
  • Wang W; School of Pharmaceutical Science and Technology Tianjin University, Tianjin 300072, PR China.
  • Qiao O; School of Pharmaceutical Science and Technology Tianjin University, Tianjin 300072, PR China.
  • Ji H; School of Pharmaceutical Science and Technology Tianjin University, Tianjin 300072, PR China.
  • Zhang X; School of Pharmaceutical Science and Technology Tianjin University, Tianjin 300072, PR China.
  • Han X; School of Pharmaceutical Science and Technology Tianjin University, Tianjin 300072, PR China.
  • Zhang Y; School of Pharmaceutical Science and Technology Tianjin University, Tianjin 300072, PR China.
  • Wang J; School of Pharmaceutical Science and Technology Tianjin University, Tianjin 300072, PR China.
  • Li X; School of Pharmaceutical Science and Technology Tianjin University, Tianjin 300072, PR China.
  • Gao W; School of Pharmaceutical Science and Technology Tianjin University, Tianjin 300072, PR China. Electronic address: pharmgao@tju.edu.cn.
Pharmacol Res ; 170: 105756, 2021 08.
Article en En | MEDLINE | ID: mdl-34237440
ABSTRACT
Chronic Cerebral Hypoperfusion(CCH)-induced vascular dementia(VD) is a common neurodegenerative disease which seriously affects the patient's quality of life. Therefore, it is critical to find an effective treatment of VD. Autophagy is a natural regulated mechanism that can remove dysfunctional proteins and organelles, however, over-activation or under-activation can of autophagy can induce the apoptosis of cells. Although autophagy plays a role in the central nervous system is unquestionable, the effects of autophagy in the ischemic brain are still controversial. Some autophagy regulators have been tested, suggesting that both activation and inhibition of autophagy can improve the cognitive function. This article reviews the role of autophagy in CCH-induced VD to discuss whether autophagy has the potential to become a target for drug development and provides several potential compounds for treating vascular dementia.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Autofagia / Productos Biológicos / Encéfalo / Demencia Vascular Límite: Animals / Humans Idioma: En Año: 2021 Tipo del documento: Article

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Autofagia / Productos Biológicos / Encéfalo / Demencia Vascular Límite: Animals / Humans Idioma: En Año: 2021 Tipo del documento: Article