MIER3 induces epithelial-mesenchymal transition and promotes breast cancer cell aggressiveness via forming a co-repressor complex with HDAC1/HDAC2/Snail.

Huang, Wenqing; Chen, Jianxiong; Liu, Xunhua; Liu, Xuming; Duan, Shiyu; Chen, Lixia; Liu, Xiaoting; Lan, Jiawen; Zou, Ying; Guo, Dan; Zhou, Jun

Huang, Wenqing; Chen, Jianxiong; Liu, Xunhua; Liu, Xuming; Duan, Shiyu; Chen, Lixia; Liu, Xiaoting; Lan, Jiawen; Zou, Ying; Guo, Dan; Zhou, Jun.

Huang W; Department of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China; Department of Pathology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, 510515, China.
Chen J; Department of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China; Department of Pathology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, 510515, China.
Liu X; Department of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China; Department of Pathology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, 510515, China.
Liu X; Department of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China; Department of Pathology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, 510515, China.
Duan S; Department of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China; Department of Pathology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, 510515, China.
Chen L; Department of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China; Department of Pathology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, 510515, China.
Liu X; Department of Pathology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, 510515, China.
Lan J; Department of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China; Department of Pathology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, 510515, China.
Zou Y; Department of Traditional Chinese Medicine, Scientific Research Platform, The Second School of Clinical Medicine, Guangdong Medical University, Dongguan, 523808, China.
Guo D; Department of Pharmacy, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China. Electronic address: gdan_2007@126.com.
Zhou J; Department of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China; Department of Pathology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, 510515, China. Electronic address: chuhang127@163.com.

Exp Cell Res ; 406(1): 112722, 2021 09 01.

Article en En | MEDLINE | ID: mdl-34242623

Asunto(s)

Neoplasias de la Mama/genética; Histona Desacetilasa 1/genética; Histona Desacetilasa 2/genética; Proteínas Nucleares/genética; Factores de Transcripción de la Familia Snail/genética; Anciano; Animales; Antígenos CD/genética; Antígenos CD/metabolismo; Neoplasias de la Mama/mortalidad; Neoplasias de la Mama/patología; Neoplasias de la Mama/terapia; Cadherinas/genética; Cadherinas/metabolismo; Línea Celular Tumoral; Movimiento Celular; Proliferación Celular; Células Epiteliales/metabolismo; Células Epiteliales/patología; Transición Epitelial-Mesenquimal/genética; Femenino; Regulación Neoplásica de la Expresión Génica; Histona Desacetilasa 1/metabolismo; Histona Desacetilasa 2/metabolismo; Humanos; Ratones Desnudos; Persona de Mediana Edad; Proteínas Nucleares/antagonistas & inhibidores; Proteínas Nucleares/metabolismo; Regiones Promotoras Genéticas; Unión Proteica; ARN Interferente Pequeño/genética; ARN Interferente Pequeño/metabolismo; Transducción de Señal/genética; Factores de Transcripción de la Familia Snail/metabolismo; Análisis de Supervivencia; Carga Tumoral; Ensayos Antitumor por Modelo de Xenoinjerto

Palabras clave

Breast cancer; EMT; HDAC; MIER3; Snail

Texto completo

Imprimir

XML

PubMed Links

Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Neoplasias de la Mama / Proteínas Nucleares / Histona Desacetilasa 1 / Histona Desacetilasa 2 / Factores de Transcripción de la Familia Snail Tipo de estudio: Prognostic_studies Idioma: En Año: 2021 Tipo del documento: Article

Texto completo

Imprimir

XML

PubMed Links

Search on Google