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Optimization of pyrazole-based compounds with 1,2,4-triazole-3-thiol moiety as selective COX-2 inhibitors cardioprotective drug candidates: Design, synthesis, cyclooxygenase inhibition, anti-inflammatory, ulcerogenicity, cardiovascular evaluation, and molecular modeling studies.
Abdellatif, Khaled R A; Abdelall, Eman K A; Elshemy, Heba A H; Philoppes, John N; Hassanein, Emad H M; Kahk, Nesma M.
  • Abdellatif KRA; Department of Pharmaceutical Organic Chemistry, Beni-Suef University, Beni-Suef 62514, Egypt. Electronic address: khaled.ahmed@pharm.bsu.edu.eg.
  • Abdelall EKA; Department of Pharmaceutical Organic Chemistry, Beni-Suef University, Beni-Suef 62514, Egypt.
  • Elshemy HAH; Department of Pharmaceutical Organic Chemistry, Beni-Suef University, Beni-Suef 62514, Egypt.
  • Philoppes JN; Department of Pharmaceutical Organic Chemistry, Beni-Suef University, Beni-Suef 62514, Egypt.
  • Hassanein EHM; Department of Pharmacology & Toxicology, Faculty of Pharmacy, Al-Azhar University, Assiut Branch, Assiut 7152, Egypt.
  • Kahk NM; Department of Pharmaceutical Organic Chemistry, Beni-Suef University, Beni-Suef 62514, Egypt.
Bioorg Chem ; 114: 105122, 2021 09.
Article en En | MEDLINE | ID: mdl-34243075
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Pirazoles / Triazoles / Cardiotónicos / Diseño de Fármacos / Antiinflamatorios no Esteroideos / Inhibidores de la Ciclooxigenasa 2 Límite: Animals Idioma: En Año: 2021 Tipo del documento: Article
Texto completo
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Pirazoles / Triazoles / Cardiotónicos / Diseño de Fármacos / Antiinflamatorios no Esteroideos / Inhibidores de la Ciclooxigenasa 2 Límite: Animals Idioma: En Año: 2021 Tipo del documento: Article