How can polyreactive antibodies conquer rapidly evolving viruses?
Trends Immunol
; 42(8): 654-657, 2021 08.
Article
en En
| MEDLINE
| ID: mdl-34246558
ABSTRACT
Broadly neutralizing antibodies against rapidly evolving viruses (e.g., HIV-1 and influenza virus), often manifest antigen-binding promiscuity. Based on a recent study, we hypothesize on the significance of antibody polyreactivity in neutralization of rapidly evolving viruses. We propose that polyreactivity contributes to toleration of viral variants and shortens the time for generating neutralizing antibodies.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Orthomyxoviridae
/
VIH-1
Límite:
Humans
Idioma:
En
Año:
2021
Tipo del documento:
Article