Effect of laparoscopic Roux-en-Y gastric bypass on improvement of insulin resistance in Type 2 diabetic patients evaluated by hyperinsulinemic-euglycemic clamp. / é«è°å²ç´ -æ£è¡èç³é³å¤¹å®éªè¯ä»·Roux-en-Yèæè·¯æ¯å¯¹2åç³å°¿ç
æ£è
è°å²ç´ æµæçæ¹åä½ç¨.
Zhong Nan Da Xue Xue Bao Yi Xue Ban
; 46(6): 609-614, 2021 Jun 28.
Article
en En, Zh
| MEDLINE
| ID: mdl-34275929
ABSTRACT
OBJECTIVES:
With the increase of people's living standards increasing year by year, Type 2 diabetes has brought great economic and living burden to the society and patients. Bariatric surgery can improve metabolic indicators in patients with diabetes, but specific mechanisms are still under study. This study aims to evaluate the effect of Roux-en-Y gastric bypass (RYGB) on insulin resistance in patients with Type 2 diabetes by hyperinsulinemic-euglycemic clamp.METHODS:
The peripheral glucose uptake (M value) of 40 patients undergoing laparoscopic Roux-en-Y gastric bypass surgery before and 6 months after the operation were analyzed hyperinsulinemic euglycemic clamp. Fasting blood glucose, glycosylated hemoglobin, triglycerides, andlow-density lipoprotein cholesterol levels as well as body mass index were also analyzed.RESULTS:
M value of patients after laparoscopic Roux-en-Y gastric bypass was significantly higher than that before the operation, while indexes such as fasting blood glucose, glycosylated hemoglobin, triglycerides, and low-density lipoprotein cholesterol levels as well as body mass index were lower than those before the operation (all P<0.05).CONCLUSIONS:
Laparoscopic Roux-en-Y gastric bypass surgery significantly improves insulin resistance in patients with Type 2 diabetes, decreases blood sugar and blood lipid, and can exert a positive effect on the treatment of Type 2 diabetes.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Resistencia a la Insulina
/
Derivación Gástrica
/
Laparoscopía
/
Diabetes Mellitus Tipo 2
Tipo de estudio:
Guideline
Límite:
Humans
Idioma:
En
/
Zh
Año:
2021
Tipo del documento:
Article