The Role of Autophagy in Chemical Proteasome Inhibition Model of Retinal Degeneration.

Gunawan, Merry; Low, Choonbing; Neo, Kurt; Yeo, Siawey; Ho, Candice; Barathi, Veluchamy A; Chan, Anita Sookyee; Sharif, Najam A; Kageyama, Masaaki

Gunawan, Merry; Low, Choonbing; Neo, Kurt; Yeo, Siawey; Ho, Candice; Barathi, Veluchamy A; Chan, Anita Sookyee; Sharif, Najam A; Kageyama, Masaaki.

Gunawan M; Santen-SERI Open Innovation Centre, 20 College Road, The Academia, Singapore 169856, Singapore.
Low C; Santen-SERI Open Innovation Centre, 20 College Road, The Academia, Singapore 169856, Singapore.
Neo K; Santen-SERI Open Innovation Centre, 20 College Road, The Academia, Singapore 169856, Singapore.
Yeo S; Translational Pre-Clinical Model Platform, Singapore Eye Research Institute, 20 College Road, The Academia, Singapore 169856, Singapore.
Ho C; Singapore Eye Research Institute, 20 College Road, The Academia, Singapore 169856, Singapore.
Barathi VA; Translational Pre-Clinical Model Platform, Singapore Eye Research Institute, 20 College Road, The Academia, Singapore 169856, Singapore.
Chan AS; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, 21 Lower Kent Ridge Road, Singapore 119077, Singapore.
Sharif NA; Academic Clinical Program in Ophthalmology, Duke-NUS Medical School, 8 College Road, Singapore 169857, Singapore.
Kageyama M; Singapore Eye Research Institute, 20 College Road, The Academia, Singapore 169856, Singapore.

Int J Mol Sci ; 22(14)2021 Jul 06.

Article en En | MEDLINE | ID: mdl-34298888

Asunto(s)

Autofagia/fisiología; Complejo de la Endopetidasa Proteasomal/metabolismo; Inhibidores de Proteasoma/farmacología; Retina/metabolismo; Degeneración Retiniana/metabolismo; Animales; Apoptosis/efectos de los fármacos; Apoptosis/fisiología; Autofagia/efectos de los fármacos; Beclina-1/metabolismo; Muerte Celular/efectos de los fármacos; Muerte Celular/fisiología; Línea Celular Tumoral; Estrés del Retículo Endoplásmico/fisiología; Humanos; Ratones; Retina/efectos de los fármacos; Serina-Treonina Quinasas TOR/metabolismo

Palabras clave

autophagy; neuroprotection; proteasome inhibition; retinal degeneration

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Retina / Degeneración Retiniana / Autofagia / Complejo de la Endopetidasa Proteasomal / Inhibidores de Proteasoma Límite: Animals / Humans Idioma: En Año: 2021 Tipo del documento: Article

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