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Hb A2-Calderdale [δ2(NA2)His→Asn; HBD: c.7C>A] and Misdiagnosis of Type 2 Diabetes Mellitus Due to Interference with Hb A1c When Using Cation Exchange High Performance Liquid Chromatography: A Case Report.
Stangerup, Ida; Petersen, Jesper; Glenthøj, Andreas.
  • Stangerup I; Department of Clinical Biochemistry, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark.
  • Petersen J; Department of Hematology, Danish Center for Hemoglobinopathies, Copenhagen, Denmark.
  • Glenthøj A; Department of Hematology, Danish Center for Hemoglobinopathies, Copenhagen, Denmark.
Hemoglobin ; 45(3): 207-209, 2021 May.
Article en En | MEDLINE | ID: mdl-34309459
ABSTRACT
The Hb A2-Calderdale variant [δ2(NA2)His→Asn, HBD c.7C>A] was described as a novel variant in 2014. However, a high performance liquid chromatography (HPLC) peak was never identified indicating that this fraction could be 'hiding' somewhere else in the chromatogram. In this case report, we present evidence that the physiochemical properties of Hb A2-Calderdale resemble those of Hb A1c, resulting in a coelution in variant mode on the Tosoh G8 but not the Tosoh G11. This coelution results in an overestimation of Hb A1c and can potentially cause misdiagnosis of type 2 diabetes mellitus (T2DM).
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Hemoglobinas Anormales / Diabetes Mellitus Tipo 2 / Errores Diagnósticos Tipo de estudio: Diagnostic_studies / Prognostic_studies Límite: Humans Idioma: En Año: 2021 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Hemoglobinas Anormales / Diabetes Mellitus Tipo 2 / Errores Diagnósticos Tipo de estudio: Diagnostic_studies / Prognostic_studies Límite: Humans Idioma: En Año: 2021 Tipo del documento: Article