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ELAVL4, splicing, and glutamatergic dysfunction precede neuron loss in MAPT mutation cerebral organoids.
Bowles, Kathryn R; Silva, M Catarina; Whitney, Kristen; Bertucci, Taylor; Berlind, Joshua E; Lai, Jesse D; Garza, Jacob C; Boles, Nathan C; Mahali, Sidhartha; Strang, Kevin H; Marsh, Jacob A; Chen, Cynthia; Pugh, Derian A; Liu, Yiyuan; Gordon, Ronald E; Goderie, Susan K; Chowdhury, Rebecca; Lotz, Steven; Lane, Keith; Crary, John F; Haggarty, Stephen J; Karch, Celeste M; Ichida, Justin K; Goate, Alison M; Temple, Sally.
  • Bowles KR; Ronald M. Loeb Center for Alzheimer's Disease, Friedman Brain Institute, Departments of Genetics and Genomic Sciences, Neuroscience, and Neurology, Icahn School of Medicine at Mount Sinai (ISMMS), New York, NY 10029, USA.
  • Silva MC; Chemical Neurobiology Laboratory, Center for Genomic Medicine, Departments of Neurology and Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
  • Whitney K; Ronald M. Loeb Center for Alzheimer's Disease, Friedman Brain Institute, Departments of Genetics and Genomic Sciences, Neuroscience, and Neurology, Icahn School of Medicine at Mount Sinai (ISMMS), New York, NY 10029, USA; Department of Pathology, Neuropathology Brain Bank and Research Core, ISMMS, N
  • Bertucci T; Neural Stem Cell Institute, Rensselaer, NY 12144, USA.
  • Berlind JE; Department of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
  • Lai JD; Department of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA; Amgen Research, One Amgen Center Dr., Thousand Oaks, CA 91320, USA.
  • Garza JC; Chemical Neurobiology Laboratory, Center for Genomic Medicine, Departments of Neurology and Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
  • Boles NC; Neural Stem Cell Institute, Rensselaer, NY 12144, USA.
  • Mahali S; Department of Psychiatry, Washington University in St. Louis, St. Louis, MO 63110, USA.
  • Strang KH; Ronald M. Loeb Center for Alzheimer's Disease, Friedman Brain Institute, Departments of Genetics and Genomic Sciences, Neuroscience, and Neurology, Icahn School of Medicine at Mount Sinai (ISMMS), New York, NY 10029, USA; Department of Pathology, Neuropathology Brain Bank and Research Core, ISMMS, N
  • Marsh JA; Department of Psychiatry, Washington University in St. Louis, St. Louis, MO 63110, USA.
  • Chen C; Department of Psychiatry, Washington University in St. Louis, St. Louis, MO 63110, USA.
  • Pugh DA; Ronald M. Loeb Center for Alzheimer's Disease, Friedman Brain Institute, Departments of Genetics and Genomic Sciences, Neuroscience, and Neurology, Icahn School of Medicine at Mount Sinai (ISMMS), New York, NY 10029, USA.
  • Liu Y; Ronald M. Loeb Center for Alzheimer's Disease, Friedman Brain Institute, Departments of Genetics and Genomic Sciences, Neuroscience, and Neurology, Icahn School of Medicine at Mount Sinai (ISMMS), New York, NY 10029, USA.
  • Gordon RE; Department of Pathology, Neuropathology Brain Bank and Research Core, ISMMS, New York, NY 10029, USA.
  • Goderie SK; Neural Stem Cell Institute, Rensselaer, NY 12144, USA.
  • Chowdhury R; Neural Stem Cell Institute, Rensselaer, NY 12144, USA.
  • Lotz S; Neural Stem Cell Institute, Rensselaer, NY 12144, USA.
  • Lane K; Neural Stem Cell Institute, Rensselaer, NY 12144, USA.
  • Crary JF; Department of Pathology, Neuropathology Brain Bank and Research Core, ISMMS, New York, NY 10029, USA.
  • Haggarty SJ; Chemical Neurobiology Laboratory, Center for Genomic Medicine, Departments of Neurology and Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
  • Karch CM; Department of Psychiatry, Washington University in St. Louis, St. Louis, MO 63110, USA.
  • Ichida JK; Department of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
  • Goate AM; Ronald M. Loeb Center for Alzheimer's Disease, Friedman Brain Institute, Departments of Genetics and Genomic Sciences, Neuroscience, and Neurology, Icahn School of Medicine at Mount Sinai (ISMMS), New York, NY 10029, USA. Electronic address: alison.goate@mssm.edu.
  • Temple S; Neural Stem Cell Institute, Rensselaer, NY 12144, USA. Electronic address: sallytemple@neuralsci.org.
Cell ; 184(17): 4547-4563.e17, 2021 08 19.
Article en En | MEDLINE | ID: mdl-34314701
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Organoides / Empalme del ARN / Proteínas tau / Ácido Glutámico / Cerebro / Proteína 4 Similar a ELAV / Mutación / Neuronas Límite: Humans Idioma: En Año: 2021 Tipo del documento: Article
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PubMed Links
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Organoides / Empalme del ARN / Proteínas tau / Ácido Glutámico / Cerebro / Proteína 4 Similar a ELAV / Mutación / Neuronas Límite: Humans Idioma: En Año: 2021 Tipo del documento: Article